Two proteins bind the same ligand, and the data is shown below. Select the best answer based on this data:
Two proteins bind the same ligand, and the data is shown below. Select the best answer based on this data:
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
Related questions
Question
Two proteins bind the same ligand, and the data is shown below. Select the best answer based on this data:
Protein A binds the ligand with higher affinity, as it has the highest KD value
Protein B binds the ligand with higher affinity, as it has the lowest KD value
Protein B binds the ligand with higher affinity, as it has the highest KD value
Protein A binds the ligand with higher affinity, as it has the lowest KD value
![[Ligand],
Protein A Protein B
nM
0.4
0.048
0.27
1
0.11
0.43
0.2
0.6
8
0.5
0.8
20
0.71
0.91
40
0.83
0.96
100
0.93
0.99](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Ff1af30ef-ee48-4eef-b80a-e9c17ca1248a%2F3c9ba093-2e1d-4338-9e33-102d999b0793%2Fhpp0wr_processed.png&w=3840&q=75)
Transcribed Image Text:[Ligand],
Protein A Protein B
nM
0.4
0.048
0.27
1
0.11
0.43
0.2
0.6
8
0.5
0.8
20
0.71
0.91
40
0.83
0.96
100
0.93
0.99
Expert Solution
Step 1
A single biomolecule's 2binding affinity is the potency of the binding relationship with its ligand (e.g. drug or inhibitor). The equilibrium dissociation constant (KD), which is used to assess and rank order the strengths of bimolecular contacts, is commonly used to measure and report binding affinity.
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