Homework Help is Here – Start Your Trial Now!
Science
Biology
kinase inhibitor that binds Kinase X and prevents ATP binding. Kinase X is part of an important signaling cascade that promotes cell growth and proliferation. Many different types of mutations can cause drug resistance, via multiple mechanisms. In some cases, the mutation underlying resistance will cause a change to the cell that allows Kinase X to resume phosphorylating its targets. However, some mutations will cause resistance independently of Kinase X activity, meaning that Kinase X will NOT phosphorylate its substrate proteins, but the cell will be resistant anyway. An example of this type of resistance would be a mutation causing conformational change of the ATP binding pocket of Kinase X increased expression of an efflux pump that removes the drug from the cell constitutive activation of a downstream kinase in the signaling cascade

kinase inhibitor that binds Kinase X and prevents ATP binding. Kinase X is part of an important signaling cascade that promotes cell growth and proliferation. Many different types of mutations can cause drug resistance, via multiple mechanisms. In some cases, the mutation underlying resistance will cause a change to the cell that allows Kinase X to resume phosphorylating its targets. However, some mutations will cause resistance independently of Kinase X activity, meaning that Kinase X will NOT phosphorylate its substrate proteins, but the cell will be resistant anyway. An example of this type of resistance would be a mutation causing conformational change of the ATP binding pocket of Kinase X increased expression of an efflux pump that removes the drug from the cell constitutive activation of a downstream kinase in the signaling cascade

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
See similar textbooks
icon
Related questions
icon
Concept explainers
Question

Give typing answer with explanation and conclusion 

You have a patient who has recently developed resistance to a treatment regimen. She is being treated with a kinase inhibitor that binds Kinase X and prevents ATP binding. Kinase X is part of an important signaling cascade that promotes cell growth and proliferation. Many different types of mutations can cause drug resistance, via multiple mechanisms. In some cases, the mutation underlying resistance will cause a change to the cell that allows Kinase X to resume phosphorylating its targets. However, some mutations will cause resistance independently of Kinase X activity, meaning that Kinase X will NOT phosphorylate its substrate proteins, but the cell will be resistant anyway. An example of this type resistance would be a mutation causing. conformational change of the ATP binding pocket of Kinase X increased expression of an efflux pump that removes the drug from the cell constitutive activation of a downstream kinase in the signaling cascade
Transcribed Image Text:You have a patient who has recently developed resistance to a treatment regimen. She is being treated with a kinase inhibitor that binds Kinase X and prevents ATP binding. Kinase X is part of an important signaling cascade that promotes cell growth and proliferation. Many different types of mutations can cause drug resistance, via multiple mechanisms. In some cases, the mutation underlying resistance will cause a change to the cell that allows Kinase X to resume phosphorylating its targets. However, some mutations will cause resistance independently of Kinase X activity, meaning that Kinase X will NOT phosphorylate its substrate proteins, but the cell will be resistant anyway. An example of this type resistance would be a mutation causing. conformational change of the ATP binding pocket of Kinase X increased expression of an efflux pump that removes the drug from the cell constitutive activation of a downstream kinase in the signaling cascade
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 4 steps

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Cancer therapy
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Recommended textbooks for you
Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
Biology
ISBN:
9780134580999
Author:
Elaine N. Marieb, Katja N. Hoehn
Publisher:
PEARSON
Biology 2e
Biology 2e
Biology
ISBN:
9781947172517
Author:
Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:
OpenStax
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781259398629
Author:
McKinley, Michael P., O'loughlin, Valerie Dean, Bidle, Theresa Stouter
Publisher:
Mcgraw Hill Education,
Molecular Biology of the Cell (Sixth Edition)
Molecular Biology of the Cell (Sixth Edition)
Biology
ISBN:
9780815344322
Author:
Bruce Alberts, Alexander D. Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter
Publisher:
W. W. Norton & Company
Laboratory Manual For Human Anatomy & Physiology
Laboratory Manual For Human Anatomy & Physiology
Biology
ISBN:
9781260159363
Author:
Martin, Terry R., Prentice-craver, Cynthia
Publisher:
McGraw-Hill Publishing Co.
Inquiry Into Life (16th Edition)
Inquiry Into Life (16th Edition)
Biology
ISBN:
9781260231700
Author:
Sylvia S. Mader, Michael Windelspecht
Publisher:
McGraw Hill Education
SEE MORE TEXTBOOKS