To preview image click here Choose the correct reagents for the following synthesis. 1. Correct reagent(s) for Step | [Select] [Select] A. PCC/CH2C12 2. Correct reagent(s) for Step II B. Na2Cr207/H2SO4/H2O A or B 3. Correct reagent(s) for Step III [Select] 4. Correct reagent(s) for Step IV [Select] 5. Correct reagents(s) for Step V [Select] -OH || OMgBr IV H OH OH
Reactive Intermediates
In chemistry, reactive intermediates are termed as short-lived, highly reactive atoms with high energy. They rapidly transform into stable particles during a chemical reaction. In specific cases, by means of matrix isolation and at low-temperature reactive intermediates can be isolated.
Hydride Shift
A hydride shift is a rearrangement of a hydrogen atom in a carbocation that occurs to make the molecule more stable. In organic chemistry, rearrangement of the carbocation is very easily seen. This rearrangement can be because of the movement of a carbocation to attain stability in the compound. Such structural reorganization movement is called a shift within molecules. After the shifting of carbocation over the different carbon then they form structural isomers of the previous existing molecule.
Vinylic Carbocation
A carbocation where the positive charge is on the alkene carbon is known as the vinyl carbocation or vinyl cation. The empirical formula for vinyl cation is C2H3+. In the vinyl carbocation, the positive charge is on the carbon atom with the double bond therefore it is sp hybridized. It is known to be a part of various reactions, for example, electrophilic addition of alkynes and solvolysis as well. It plays the role of a reactive intermediate in these reactions.
Cycloheptatrienyl Cation
It is an aromatic carbocation having a general formula, [C7 H7]+. It is also known as the aromatic tropylium ion. Its name is derived from the molecule tropine, which is a seven membered carbon atom ring. Cycloheptatriene or tropylidene was first synthesized from tropine.
Stability of Vinyl Carbocation
Carbocations are positively charged carbon atoms. It is also known as a carbonium ion.
![**Synthetic Pathway Selection Activity**
In this exercise, you will choose the correct reagents necessary for each step in a multi-step organic synthesis process.
**Instructions:**
For each step (I-V) in the synthesis, select the appropriate reagent(s) from the dropdown menu.
1. **Correct reagent(s) for Step I**
- [ Select ]
- Options:
- A. PCC/CH2Cl2
- B. Na2Cr2O7/H2SO4/H2O
- A or B
2. **Correct reagent(s) for Step II**
- [ Select ]
3. **Correct reagent(s) for Step III**
- [ Select ]
4. **Correct reagent(s) for Step IV**
- [ Select ]
5. **Correct reagent(s) for Step V**
- [ Select ]
**Reaction Diagram Description:**
- **Step I:** The starting material is a cyclic alcohol compound. The goal is to transform the alcohol group into an aldehyde.
- **Step II:** This involves the conversion of the aldehyde into a different functional group, resulting in a compound with a lactone structure.
- **Step III:** The lactone is modified further, preserving the ring structure.
- **Step IV:** The compound undergoes a Grignard reaction, introducing a magnesium bromide group (OMgBr).
- **Step V:** The final step involves converting the Grignard intermediate to an amine alcohol product.
This activity will help solidify your understanding of reagent selection in organic synthesis pathways.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fd28bb5a8-7114-481e-95e9-134d2c6aa143%2Fa5b8da60-f591-49f6-8c24-b8b4084e024b%2F9j7svwd_processed.jpeg&w=3840&q=75)
![To preview image click here
Choose the correct reagents for the following synthesis.
1. Correct reagent(s) for Step I
- [ Select ]
2. Correct reagent(s) for Step II
- [ Select ]
Options:
A. HOCH2CH2OH/ROH
B. 1 Equivalent HOCH2CH2OH/HCl (cat.)
C. 2 Equivalent HOCH2CH2OH/HCl (cat.)
3. Correct reagent(s) for Step III
- [ Select ]
4. Correct reagent(s) for Step IV
- [ Select ]
5. Correct reagent(s) for Step V
- [ Select ]
Diagram:
- **Step I**: Starts with a cyclic compound with an alcohol and a ketone group.
- **Step II**: Transformation involves the formation of another cyclic compound with an additional ketone group.
- **Step III**: Another structural change leading to a cyclic ketone with an ester or related group.
- **Step IV**: Introduction of a Grignard reagent (OMgBr) structure.
- **Step V**: Final step leading to the formation of a compound with an additional hydroxide and amine group.
The sequence displays the progression of a multi-step chemical synthesis involving cyclic compounds and functional group transformations.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fd28bb5a8-7114-481e-95e9-134d2c6aa143%2Fa5b8da60-f591-49f6-8c24-b8b4084e024b%2Fw621qec_processed.jpeg&w=3840&q=75)
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