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This DNA molecule has eight copies of a CAG repeat. GYC The two strands separate. GOGICGCGOGICGIGICGE and replicate. GICGTCGICGTC GICGTCGTCGTC CAGCAG CACCAG CAGCAGCAG GICGIC CAGCAG GICGTEGICGTCGCGTA CAG In the course of replication, a hairpin forms on the newly synthesized strand,. র 9 10 11 12 13 3 causing part of the template strand to be repicated twice and increasing the number of repeats on the newly synthesized strand. The two strands of the new DNA molecule separate,. ে AGCAG 12 13 2 and the strand with extra CAG copies serves as a template for replication 9 10 11 12 13 7 8,9 10 11 12 13 B The resulting DNA molecule contairs five additional copies of the CAG repeat TABLE 18.1 Examples of human genetic diseases caused by expanding nucleotide repeats Number of Copies of Repeat Disease Repeated Sequence Normal Disease Range Range Spinal and bulbar muscular atrophy Fragile-X syndrome Jacobsen syndrome Spinocerebellar ataxia (several types) Autosomal dominant cerebellar ataxia Myotonic dystrophy Huntington disease Friedreich ataxia Dentatorubral-pallidoluysian atrophy Myoclonus epilepsy of the Unverricht- CCCCGCCCCGCG 2-3 Lundborg type Amyotrophic lateral sclerosis CAG 11-33 40-62 CGG 6-54 50-1500 CGG 11 100-1000 CAG 4-44 21-130 CAG 7-19 37-220 CTG 5-37 44-3000 CAG 9-37 37-121 GAA 6-29 200-900 CAG 7-25 49-75 12-13 GGGGCC 2-23 700-1600

This DNA molecule has eight copies of a CAG repeat. GYC The two strands separate. GOGICGCGOGICGIGICGE and replicate. GICGTCGICGTC GICGTCGTCGTC CAGCAG CACCAG CAGCAGCAG GICGIC CAGCAG GICGTEGICGTCGCGTA CAG In the course of replication, a hairpin forms on the newly synthesized strand,. র 9 10 11 12 13 3 causing part of the template strand to be repicated twice and increasing the number of repeats on the newly synthesized strand. The two strands of the new DNA molecule separate,. ে AGCAG 12 13 2 and the strand with extra CAG copies serves as a template for replication 9 10 11 12 13 7 8,9 10 11 12 13 B The resulting DNA molecule contairs five additional copies of the CAG repeat TABLE 18.1 Examples of human genetic diseases caused by expanding nucleotide repeats Number of Copies of Repeat Disease Repeated Sequence Normal Disease Range Range Spinal and bulbar muscular atrophy Fragile-X syndrome Jacobsen syndrome Spinocerebellar ataxia (several types) Autosomal dominant cerebellar ataxia Myotonic dystrophy Huntington disease Friedreich ataxia Dentatorubral-pallidoluysian atrophy Myoclonus epilepsy of the Unverricht- CCCCGCCCCGCG 2-3 Lundborg type Amyotrophic lateral sclerosis CAG 11-33 40-62 CGG 6-54 50-1500 CGG 11 100-1000 CAG 4-44 21-130 CAG 7-19 37-220 CTG 5-37 44-3000 CAG 9-37 37-121 GAA 6-29 200-900 CAG 7-25 49-75 12-13 GGGGCC 2-23 700-1600

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Draw a hairpin structure like that shown in Figure 18.5 for the repeated sequence found in fragile-X syndrome (see Table 18.1).

This DNA molecule has eight copies of a CAG repeat. GYC The two strands separate. GOGICGCGOGICGIGICGE and replicate. GICGTCGICGTC GICGTCGTCGTC CAGCAG CACCAG CAGCAGCAG GICGIC CAGCAG GICGTEGICGTCGCGTA CAG In the course of replication, a hairpin forms on the newly synthesized strand,. র 9 10 11 12 13 3 causing part of the template strand to be repicated twice and increasing the number of repeats on the newly synthesized strand. The two strands of the new DNA molecule separate,. ে AGCAG 12 13 2 and the strand with extra CAG copies serves as a template for replication 9 10 11 12 13 7 8,9 10 11 12 13 B The resulting DNA molecule contairs five additional copies of the CAG repeat
Transcribed Image Text:This DNA molecule has eight copies of a CAG repeat. GYC The two strands separate. GOGICGCGOGICGIGICGE and replicate. GICGTCGICGTC GICGTCGTCGTC CAGCAG CACCAG CAGCAGCAG GICGIC CAGCAG GICGTEGICGTCGCGTA CAG In the course of replication, a hairpin forms on the newly synthesized strand,. র 9 10 11 12 13 3 causing part of the template strand to be repicated twice and increasing the number of repeats on the newly synthesized strand. The two strands of the new DNA molecule separate,. ে AGCAG 12 13 2 and the strand with extra CAG copies serves as a template for replication 9 10 11 12 13 7 8,9 10 11 12 13 B The resulting DNA molecule contairs five additional copies of the CAG repeat
TABLE 18.1 Examples of human genetic diseases caused by expanding nucleotide repeats Number of Copies of Repeat Disease Repeated Sequence Normal Disease Range Range Spinal and bulbar muscular atrophy Fragile-X syndrome Jacobsen syndrome Spinocerebellar ataxia (several types) Autosomal dominant cerebellar ataxia Myotonic dystrophy Huntington disease Friedreich ataxia Dentatorubral-pallidoluysian atrophy Myoclonus epilepsy of the Unverricht- CCCCGCCCCGCG 2-3 Lundborg type Amyotrophic lateral sclerosis CAG 11-33 40-62 CGG 6-54 50-1500 CGG 11 100-1000 CAG 4-44 21-130 CAG 7-19 37-220 CTG 5-37 44-3000 CAG 9-37 37-121 GAA 6-29 200-900 CAG 7-25 49-75 12-13 GGGGCC 2-23 700-1600
Transcribed Image Text:TABLE 18.1 Examples of human genetic diseases caused by expanding nucleotide repeats Number of Copies of Repeat Disease Repeated Sequence Normal Disease Range Range Spinal and bulbar muscular atrophy Fragile-X syndrome Jacobsen syndrome Spinocerebellar ataxia (several types) Autosomal dominant cerebellar ataxia Myotonic dystrophy Huntington disease Friedreich ataxia Dentatorubral-pallidoluysian atrophy Myoclonus epilepsy of the Unverricht- CCCCGCCCCGCG 2-3 Lundborg type Amyotrophic lateral sclerosis CAG 11-33 40-62 CGG 6-54 50-1500 CGG 11 100-1000 CAG 4-44 21-130 CAG 7-19 37-220 CTG 5-37 44-3000 CAG 9-37 37-121 GAA 6-29 200-900 CAG 7-25 49-75 12-13 GGGGCC 2-23 700-1600
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