The Problem The three diseases in this study are borne out of errors that involve certain components of the Krebs Cycle. These conditions have a wide array of manifestations that can be seen as early as infancy. Since this pathway is central to energy production, it can affect most types of tissue, with most of the symptoms observed in nerve and muscle tissues. (Rustin et al., 1997)  Given the clinical manifestations, what suggestion do you have pertaining to the management of the diseases: a-KG dehydrogenase, succinate dehydrogenase (SDH) and fumarase?

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