The molecular ion region in the mass spectrum of a large molecule, such as a protein, consists of a cluster of peaks differing by 1 Da. This pattern occurs because a molecule with many atoms has a high probability of containing one or several atoms of 13 C, 15N, 180, 2H and 34S. The probability of finding a molecule with only 12C, 14N, 160, 'H and 32S may be so small that the nominal molecular ion is not observed. The electrospray mass spectrum of the rat protein interleukin-8 consists of a series of clusters of peaks arising from intact molecular ions with different charge. One cluster has peaks at m/z 1961.12, 1961.35, 1961.63, 1961.88, 1962.12 (tallest peak), 1962.36, 1962.60, 1962.87, 1963.10, 1963.34, 1963.59,1963.85, and 1964.09. These peaks correspond to isotopic ions differing by 1 Da. From the observed peak separation, find the charge of the ions in this cluster. Z=
The molecular ion region in the mass spectrum of a large molecule, such as a protein, consists of a cluster of peaks differing by 1 Da. This pattern occurs because a molecule with many atoms has a high probability of containing one or several atoms of 13 C, 15N, 180, 2H and 34S. The probability of finding a molecule with only 12C, 14N, 160, 'H and 32S may be so small that the nominal molecular ion is not observed. The electrospray mass spectrum of the rat protein interleukin-8 consists of a series of clusters of peaks arising from intact molecular ions with different charge. One cluster has peaks at m/z 1961.12, 1961.35, 1961.63, 1961.88, 1962.12 (tallest peak), 1962.36, 1962.60, 1962.87, 1963.10, 1963.34, 1963.59,1963.85, and 1964.09. These peaks correspond to isotopic ions differing by 1 Da. From the observed peak separation, find the charge of the ions in this cluster. Z=
Chemistry & Chemical Reactivity
10th Edition
ISBN:9781337399074
Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel
Chapter2: Atoms Molecules And Ions
Section: Chapter Questions
Problem 100PS
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Transcribed Image Text:The molecular ion region in the mass spectrum of a large molecule, such as a protein, consists of a cluster of peaks differing by
1 Da. This pattern occurs because a molecule with many atoms has a high probability of containing one or several atoms of
13 C, 15N, 180, 2H and 34S. The probability of finding a molecule with only 12C, 14N, 160, 'H and 32S may be so small that the
nominal molecular ion is not observed. The electrospray mass spectrum of the rat protein interleukin-8 consists of a series of
clusters of peaks arising from intact molecular ions with different charge. One cluster has peaks at m/z 1961.12, 1961.35,
1961.63, 1961.88, 1962.12 (tallest peak), 1962.36, 1962.60, 1962.87, 1963.10, 1963.34, 1963.59,1963.85, and 1964.09. These
peaks correspond to isotopic ions differing by 1 Da. From the observed peak separation, find the charge of the ions in
this cluster.
Z=
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