The manganese ion in the center is attached to aspartate ligand, 1 cysteine ligand, and 2 istidine ligands. The glutamate residue on the pottom is hydrogen bonded to the histidine side chain. The pKa of the water that is attached on on is 7

Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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The manganese ion in the center is attached to 1
aspartate ligand, 1 cysteine ligand, and 2
histidine ligands. The glutamate residue on the
bottom is hydrogen bonded to the histidine side
chain. The pKa of the water that is attached on
top is 7.
Part a) If the cysteine ligand was changed to a
histidine ligand, how would the pka of the water
change? Explain.
Part b) If the glutamate residue was changed to
leucine, how would the pka of the water change?
Explain.
OHz
His
Transcribed Image Text:The manganese ion in the center is attached to 1 aspartate ligand, 1 cysteine ligand, and 2 histidine ligands. The glutamate residue on the bottom is hydrogen bonded to the histidine side chain. The pKa of the water that is attached on top is 7. Part a) If the cysteine ligand was changed to a histidine ligand, how would the pka of the water change? Explain. Part b) If the glutamate residue was changed to leucine, how would the pka of the water change? Explain. OHz His
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