The image below shows the base cytosine and a methylated form of cytosine that occurs frequently in the human genome. Use your knowledge of DNA structure to answer the following questions: a) Does methylation of cytosine affect its ability to base-pair with guanine? Explain your answer. b) Would methylation of cytosine affect the binding of a protein that interacts with a C-G base-pair in the major groove?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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The image below shows the base cytosine and a methylated form of cytosine that occurs frequently in the human genome. Use your knowledge of DNA structure to answer the following questions:

a) Does methylation of cytosine affect its ability to base-pair with guanine? Explain your answer.

b) Would methylation of cytosine affect the binding of a protein that interacts with a C-G base-pair in the major groove?

 

ŅH2
CH3
NH2
N-
Methylation
`N
Demethylation
DŇA
DŇA
Cytosine
5-Methylcytosine
Transcribed Image Text:ŅH2 CH3 NH2 N- Methylation `N Demethylation DŇA DŇA Cytosine 5-Methylcytosine
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