The fates of a million implanted human zygotes 1,000,000 conceptions 150,000 spontaneous abortions 850,000 live births 833,000 children 17,000 perinatal deaths 75,000 chromosome abnormalities 39,000 trisomics (3,510 trisomy 21) 5,165 chromosome abnormalities 13,500 XO 1,849 sex chromosome aneuploids 1,427 males 422 females F 12,750 triploids – 4,500 tetraploids 42 trisomy 13 100 trisomy 18 1,041 trisomy 21 1,183 autosomal 5,250 others trisomics 758 balanced Robertsonian translocations 758 balanced reciprocal translocations 117 inversions 500 unbalanced structural aberrations FIGURE 17-37 The proportion of chromosomal mutations is much higher in spontaneous abortions. [Data from K. Sankaranarayanan, Mutat. Res. 61, 1979, 249–257)]

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Chapter20: The Reproductive System
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Using Figure 17-37, calculate what percentage of conceptions are triploid. The same figure shows XO in the spontaneous-abortion category; however, we know that many
XO individuals are viable. In which of the viable categories would XO be grouped?

The fates of a million implanted human zygotes
1,000,000
conceptions
150,000
spontaneous abortions
850,000
live births
833,000
children
17,000
perinatal deaths
75,000
chromosome abnormalities
39,000 trisomics
(3,510 trisomy 21)
5,165
chromosome abnormalities
13,500 XO
1,849 sex chromosome
aneuploids
1,427 males
422 females
F 12,750 triploids
– 4,500 tetraploids
42 trisomy 13
100 trisomy 18
1,041 trisomy 21
1,183 autosomal
5,250 others
trisomics
758 balanced
Robertsonian
translocations
758 balanced
reciprocal
translocations
117 inversions
500 unbalanced
structural aberrations
FIGURE 17-37 The proportion of chromosomal mutations is much higher in spontaneous
abortions. [Data from K. Sankaranarayanan, Mutat. Res. 61, 1979, 249–257)]
Transcribed Image Text:The fates of a million implanted human zygotes 1,000,000 conceptions 150,000 spontaneous abortions 850,000 live births 833,000 children 17,000 perinatal deaths 75,000 chromosome abnormalities 39,000 trisomics (3,510 trisomy 21) 5,165 chromosome abnormalities 13,500 XO 1,849 sex chromosome aneuploids 1,427 males 422 females F 12,750 triploids – 4,500 tetraploids 42 trisomy 13 100 trisomy 18 1,041 trisomy 21 1,183 autosomal 5,250 others trisomics 758 balanced Robertsonian translocations 758 balanced reciprocal translocations 117 inversions 500 unbalanced structural aberrations FIGURE 17-37 The proportion of chromosomal mutations is much higher in spontaneous abortions. [Data from K. Sankaranarayanan, Mutat. Res. 61, 1979, 249–257)]
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