A human male named Phillip has an X chromosome that ismissing its Xic. Is this caused by a new mutation (one that occurredduring gametogenesis), or could this mutation have occurred in anearlier generation and be found in the somatic cells of one of hisparents? Explain your answer. How would this mutation affect hisability to produce viable offspring?
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A human male named Phillip has an X chromosome that is
missing its Xic. Is this caused by a new mutation (one that occurred
during gametogenesis), or could this mutation have occurred in an
earlier generation and be found in the somatic cells of one of his
parents? Explain your answer. How would this mutation affect his
ability to produce viable offspring?
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- Over a period of two years, a man in his early 20s receiveda series of intermittent chemotherapy and radiotherapytreatments for Hodgkin disease. During this therapy, heand his wife were unable to initiate a pregnancy. The man had aseries of his semen samples examined at a fertility clinic. The findings revealed that shortly after each treatment very few mature sperm were present, and abnormal chromosome numbers were often observed in developing spermatocytes. However, such chromosome abnormalities disappeared about 40 days after treatment, and normal sperm reappeared about 74 days posttreatment. Prior to treatment, should the physician(s) involved have beenethically obligated to recommend genetic counseling? Whatadvice regarding fertility might have been suggested?Over a period of two years, a man in his early 20s receiveda series of intermittent chemotherapy and radiotherapytreatments for Hodgkin disease. During this therapy, heand his wife were unable to initiate a pregnancy. The man had aseries of his semen samples examined at a fertility clinic. The findings revealed that shortly after each treatment very few mature sperm were present, and abnormal chromosome numbers were often observed in developing spermatocytes. However, such chromosome abnormalities disappeared about 40 days after treatment, and normal sperm reappeared about 74 days posttreatment. How might a genetic counselor explain the time-related differences in sperm production and the appearance and subsequent disappearance of chromosomal abnormalities?Carbon Copy (CC), the first cat produced from aclone, was created from an ovarian cell taken from hergenetic donor, Rainbow, a calico cat. The diploid nucleusfrom the cell was extracted and then injected into an enucleatedegg. The resulting zygote was then allowed to developin a petri dish, and the cloned embryo was implanted inthe uterus of a surrogate mother cat, who gave birth to CC.CC’s surrogate mother was a tabby (see the photo below).Geneticists were very interested in the outcome of cloninga calico cat because they were not certain if the cloned catwould have patches of orange and black, just orange, orjust black. Taking into account the Lyon hypothesis, explainthe basis of the uncertainty. Would you expect CC to appearidentical to Rainbow? Explain why or why not.
- A diploid species has four chromosomes per set for a total of eightchromosomes in its somatic cells. Draw such a cell as it wouldlook in late prophase of meiosis II and prophase of mitosis. Discuss how prophase of meiosis II and prophase of mitosis differfrom each other, and explain how the difference originates.The process of oogenesis is often described as theproduction of a haploid egg by meiosis, but in someanimals, including humans, this description is notentirely accurate. Explain.A female Komodo dragon (Varanus komodoensis) kept inisolation in a zoo had progeny. Each of the offspring had twoidentical copies of every gene in its genome. However, theoffspring were not identical to one another. Based on yourunderstanding of parthenogenesis and meiosis, propose ahypothesis to explain these observations.
- During oogenesis, nondisjunction of X chromosome occurred in meiosis I. If the resulting egg unites with normal sperm, what genetic disorder(s) would be produced in live-birth offspring? Explain why?On rare occasions, people are born with a condition known as uniparental disomy. It happens when an individual inherits both copies of achromosome from one parent and no copies from the other parent. Thisoccurs when two abnormal gametes happen to complement each otherto produce a diploid zygote. For example, an abnormal sperm thatlacks chromosome 15 could fertilize an egg that contains two copies ofchromosome 15. In this situation, the individual has maternal uniparental disomy 15 because both copies of chromosome 15 were inheritedfrom the mother. Alternatively, an abnormal sperm with two copies ofchromosome 15 could fertilize an egg with no copies. This is known aspaternal uniparental disomy 15. If a female is born with paternal uniparental disomy 15, would you expect her to be phenotypically normal,have Angelman syndrome (AS), or have Prader-Willi syndrome(PWS)? Explain. Would you expect her to produce normal offspring oroffspring affected with AS or PWS?In a possible future scenario, male fertility drops to zero, but, luckily, scientists develop a way for women to pro-duce babies by virgin birth. Meiocytes are converted di-rectly (without undergoing meiosis) into zygotes, which implant in the usual way. What would be the short- andlong-term effects in such a society?
- A teratogen is an agent that produces nongenetic abnormalities during embryonic or fetal development. Suppose a teratogen is present at conception. As a result, during the first mitotic division the centromeres fail to divide. The teratogen then loses its potency and has no further effect on the embryo. What is the chromosomal complement of this embryo?normal somatic cells of an organism have 100 chromosomes. how many chromosomes will be present in the first polar body of that organism during gamete formationChoose the best matching phrase in the right columnfor each of the terms in the left column.a. meiosis 1. X and Yb. gametes 2. chromosomes that do not differbetween the sexesc. karyotype 3. one of the two identical halvesof a replicated chromosomed. mitosis 4. microtubule organizing centersat the spindle polese. interphase 5. cells in the testes that undergomeiosisf. syncytium 6. division of the cytoplasmg. synapsis 7. haploid germ cells that uniteat fertilizationh. sex chromosomes 8. an animal cell containing morethan one nucleusi. cytokinesis 9. pairing of homologouschromosomesj. anaphase 10. one diploid cell gives rise to twodiploid cellsk. chromatid 11. the array of chromosomes in agiven celll. autosomes 12. the part of the cell cycle duringwhich the chromosomes are notvisiblem. centromere 13. one diploid cell gives rise to fourhaploid cellsn. centrosomes 14. cell produced by meiosis thatdoes not become a gameteo. polar body 15. the time during mitosis whensister chromatids…