Over a period of two years, a man in his early 20s receiveda series of intermittent chemotherapy and radiotherapytreatments for Hodgkin disease. During this therapy, heand his wife were unable to initiate a pregnancy. The man had aseries of his semen samples examined at a fertility clinic. The findings revealed that shortly after each treatment very few mature sperm were present, and abnormal chromosome numbers were often observed in developing spermatocytes. However, such chromosome abnormalities disappeared about 40 days after treatment, and normal sperm reappeared about 74 days posttreatment. How might a genetic counselor explain the time-related differences in sperm production and the appearance and subsequent disappearance of chromosomal abnormalities?
Over a period of two years, a man in his early 20s received
a series of intermittent chemotherapy and radiotherapy
treatments for Hodgkin disease. During this therapy, he
and his wife were unable to initiate a pregnancy. The man had a
series of his semen samples examined at a fertility clinic. The findings revealed that shortly after each treatment very few mature sperm were present, and abnormal chromosome numbers were often observed in developing spermatocytes. However, such chromosome abnormalities disappeared about 40 days after treatment, and normal sperm reappeared about 74 days posttreatment.
How might a genetic counselor explain the time-related differences in sperm production and the appearance and subsequent disappearance of chromosomal abnormalities?
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