The conversion of glucose to glucose-6-phosphate is the first reaction ofglycolysis. This reaction requires hexokinase, Mg** ions as enzyme andcofactor, and ATP as substrate. What is the significance of Mg²+ ions in thisreaction?

In the first step of glycolysis, the glucose ring is phosphorylated. Phosphorylation is the process…

Answered: The conversion of glucose to…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Discuss the composition of the transition state for the formation of ATP by ATP Synthase. a) Where is the active site for this enzyme located? b) How are the amino acid side chains from the α and β subunits of ATP Synthase involved? c) Discuss the importance of Mg+2 in the mechanism of this enzyme.
Hexokinase is found in almost all animal cells, except the liver and pancreas, while glucokinase is found only in the liver and pancreas. How do these enzymes differ in terms of activity and regulation?
Why is this reaction crucial to ATP synthesis in glycolysis?
Which reaction in the citric acid cycle is most analogous to the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate? What kind of enzymebound intermediate is formed in both reactions?
Which of the following is the correct summary of phase II of glycolysis for each molecule of glucose? Glucose + ATP ⟶ Glyceraldehy-3-phosphate + ADP Glucose + 2 ATP ⟶ 2(Glyceraldehy-3-phosphate) + 2 ADP Glyceraldehyde-3-phosphate + NAD+ + ADP + Pi ⟶ 3-phosphoglycerate + NADH + H+ + ATP 2(3-phosphoglycerate) + 2ADP ⟶ 2 pyruvate + 2ATP 2(Glyceraldehyde-3-phosphate) + 2NAD+ + 2ADP + 2Pi ⟶ 2(3-phosphoglycerate) + 2NADH + 2H+ + 2ATP
In a major metabolic pathway involving the monosaccharide glucose, one of the reactions involve the conversion of glucose to glucose-6-phosphate summarized below together with accompanying free energy change: glucose + phosphate = glucose-6-phosphate + H,0 AG = 13.8 kJ · mol-1 (Reaction 1) In cells, the production of G6P (Reaction 1 above) is coupled to a reaction that involves the hydrolysis of ATP to ADP (shown below, Reaction 2) which makes the overall reaction much more favorable to the production of glucose-6-phosphate. ATP + H,O = ADP + phosphate (Reaction 2) Why do you think coupling the production of glucose-6-phosphate to the hydrolysis of ATP makes the overall reaction spontaneous? What can you say about the free energy change accompanying the hydrolysis of ATP (Reaction 2)?
Show the complete reaction mechanism (including arrow pushing) for this reaction.
Which reactions of glycolysis can be reversed? Which are irreversible? What is the significance of the metabolically irreversible reactions?
The first reaction in glycolysis is the phosphorylation of glucose to form glucose 6-phosphate: P₁+ glucose glucose 6-phosphate + H₂O This is a thermodynamically unfavorable reaction, with AG° = +13.8 kJ/mol. a) In a liver cell at 37°C the concentrations of both phosphate and glucose are normally maintained at about 5 mM each. What is the equilibrium concentration of glucose 6- phosphate, according to the above reaction? b) This very low concentration of glucose 6-phosphate is unfavorable for glycolysis. In fact, the reaction is coupled to the hydrolysis of ATP: ATP + H₂O2 ADP + P₁ +H* AG°¹ = -32.2 kJ/mol Write the expression for the overall reaction and calculate AG°¹. c) In addition to the glucose and phosphate concentrations listed in part (a) above, assume that the liver cell concentrations of ATP and ADP are 3 mM and 1 mM, respectively. Calculate the theoretical equilibrium concentration of glucose 6-phosphate at pH = 7.4 and 37 °C. C ZOOM +
The following nutrient molecule is digested and transported to a cell where it undergoes further catabolism: HO HO он OH HO- OH OH OH In the table below, list the important products of the complete glycolysis of this molecule. • In the first column of the table, write the chemical formula, name, or standard biochemical symbol for a product molecule. In the second column, write the total number of these molecules produced. Add Row • Only list the important products, including (1) molecules with any of the carbon atoms originally in the molecule above, (2) energy storage molecules (like ATP), and (3) any newly oxidized or reduced coenzymes. • List each product molecule on a separate row. You can add more rows to the table if you need them. • Be sure you write the number of product molecules formed by the complete glycolysis of the molecule above. • If the molecules does not undergo glycolysis at all, check the box under the table and leave the table blank. product (name, chemical…
Organisms growing anaerobically cannot perform glycolysis for long without reducing the pyruvate from glycolysis into another compound, most commonly to lactate or to ethanol plus CO2. Both of these reactions are given below in their unbalanced forms. Explain in one sentence why one of these reducing steps is needed to sustain anaerobic glycolysis.
Of the 36 molecules of ATP produced by the complete metabolism of glucose, how many are produced directly in glycolysis alone, that is, before the common pathway?

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The conversion of glucose to glucose-6-phosphate is the first reaction of glycolysis. This reaction requires hexokinase, Mg** ions as enzyme and cofactor, and ATP as substrate. What is the significance of Mg²+ ions in this reaction?