The concentration of acetylcholine (a neurotransmitter) in a sample can be determined from the pH changes that accompany its hydrolysis. When the sample is incubated with the enzyme acetylcholinesterase, acetylcholine is converted to choline and acetic acid, which dissociates to yield acetate and a hydrogen ion. CНз CHз Нао — сHz— CH "N— снз но-сн— сH,-"N-CH; + CH;— с-о+ н* CH3-C-0- сHз CHз Choline Acetylcholine Acetate In a typical analysis, 11 mL of an aqueous solution containing an unknown amount of acetylcholine had a pH of 7.70. When incubated with acetylcholinesterase, the pH of the solution decreased to 6.89. Assuming there was no buffer in the assay mixture, determine the number of moles of acetylcholine in the 11 mL sample.

The concentration of acetylcholine (a neurotransmitter) in a sample can be determined from the pH changes that accompany its hydrolysis. When the sample is incubated with the enzyme acetylcholinesterase, acetylcholine is converted to choline and acetic acid, which dissociates to yield acetate and a hydrogen ion. CНз CHз Нао — сHz— CH "N— снз но-сн— сH,-"N-CH; + CH;— с-о+ н* CH3-C-0- сHз CHз Choline Acetylcholine Acetate In a typical analysis, 11 mL of an aqueous solution containing an unknown amount of acetylcholine had a pH of 7.70. When incubated with acetylcholinesterase, the pH of the solution decreased to 6.89. Assuming there was no buffer in the assay mixture, determine the number of moles of acetylcholine in the 11 mL sample.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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The preparations of two aqueous solutions are described in the table below. For each solution, write the chemical formulas of the major species present at equilibrium. You can leave out water itself. Write the chemical formulas of the species that will act as acids in the 'acids' row, the formulas of the species that will act as bases in the 'bases' row, and the formulas of the species that will act as neither acids nor bases in the 'other' row. You will find it useful to keep in mind that NH, is a weak base. acids: 1.0 mol of HNO, is added to 1.0 L of a 1.0 M NH, bases: O solution other: 0.2 mol of HBr is added to O acids: 1.0 L of a solution that is O. bases: 0.7 M in both NH, and NH Br. other: Check Explanation 2021 McGraw-Hi Education. All Rights Reserved. Terms of Use Privacy Accessibility
The preparations of two aqueous solutions are described in the table below. For each solution, write the chemical formulas of the major species present at equilibrium. You can leave out water itself. Write the chemical formulas of the species that will act as acids in the 'acids' row, the formulas of the species that will act as bases in the 'bases' row, and the formulas of the species that will act as neither acids nor bases in the 'other' row. You will find it useful to keep in mind that HCH,CO, is a weak acid. acids: 1.4 mol of NaOH is added to 1.0 L of a 1.4M HCH,CO, bases: solution. other: || 0.2 mol of HBr is added to acids: 1.0 L of a solution that is bases: 0.6M in both HCH,CO, and KCH,CO,. other:
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