The catalytic mechanism of bovine pancreatic RNase A relies upon acid-base catalysis involving the amino acid imidazole lysine histidine aspartic acid Oglutamic acid

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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**Question: The catalytic mechanism of bovine pancreatic RNase A relies upon acid-base catalysis involving the amino acid ________.**

- ○ imidazole
  
- ○ lysine

- ○ histidine

- ○ aspartic acid

- ○ glutamic acid
Transcribed Image Text:**Question: The catalytic mechanism of bovine pancreatic RNase A relies upon acid-base catalysis involving the amino acid ________.** - ○ imidazole - ○ lysine - ○ histidine - ○ aspartic acid - ○ glutamic acid
### Enzyme Kinetic Constants and Drug Effects

You are studying the effects of a new drug on the activity of the enzyme elevated in response to a disease. The results of your studies show the drug is acting as a pure noncompetitive inhibitor. Which of the following changes to the enzyme kinetic constants will occur from this drug's actions? 

(Choose all correct answers)

- [ ] Km will increase
- [ ] Km will remain unchanged
- [ ] Vmax will decrease
- [ ] Vmax will remain unchanged
- [ ] k_cat (turnover number) will decrease
Transcribed Image Text:### Enzyme Kinetic Constants and Drug Effects You are studying the effects of a new drug on the activity of the enzyme elevated in response to a disease. The results of your studies show the drug is acting as a pure noncompetitive inhibitor. Which of the following changes to the enzyme kinetic constants will occur from this drug's actions? (Choose all correct answers) - [ ] Km will increase - [ ] Km will remain unchanged - [ ] Vmax will decrease - [ ] Vmax will remain unchanged - [ ] k_cat (turnover number) will decrease
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