The BOC-protecting group may be added by treatment of an amino acid with di-tert- butyl dicarbonate as shown in the following reaction sequence. Propose a mechanism to account for formation of these products. (CH3),COCOČOC(CH3), + H2NCHCOO- (CH),COČNHCHCOO-+ (CH,),COH + CO, Di-tert-butyl dicarbonate BOC-amino acid

The BOC-protecting group may be added by treatment of an amino acid with di-tert- butyl dicarbonate as shown in the following reaction sequence. Propose a mechanism to account for formation of these products. (CH3),COCOČOC(CH3), + H2NCHCOO- (CH),COČNHCHCOO-+ (CH,),COH + CO, Di-tert-butyl dicarbonate BOC-amino acid

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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