**Malonic Ester Synthesis****Question 4:**Write the reactions showing all intermediates when H(COOC₂H₅)₂ (diethyl malonate) is reacted with:1. NaOEt2. Ethyl iodide3. NaOH4. H₃O⁺5. Heat (Δ)**Hint:** Remember that β-keto carboxylic acids undergo decarboxylation (loss of 1 equivalent of CO₂) when strongly heated.---**Explanation:**This question pertains to the malonic ester synthesis, a method used to form substituted acetic acids. The process involves multiple steps:1. **NaOEt (Sodium Ethoxide):** Acts as a base to deprotonate diethyl malonate, forming a carbanion.2. **Ethyl Iodide:** Alkylates the ester via the carbanion, introducing an alkyl group.3. **NaOH (Sodium Hydroxide):** Hydrolyzes the esters to a dicarboxylic acid.4. **H₃O⁺ (Acid):** Protonates the dicarboxylate anion, giving the free diacid form.5. **Heat (Δ):** Causes decarboxylation, resulting in the formation of a β-keto acid that loses CO₂ to form a ketone.These steps illustrate the transformation of diethyl malonate into a substituted acetic acid derivative via decarboxylation.

This is Nucleophilic substitution reaction. NaOEt (sodium ethoxide) is a strong base it abstract…

Malonic ester synthesis 4. Write the reaction showing all intermediates when H₂C(CO₂Et)2 (diethyl malonate) is reacted with NaOEt followed by 1) ethyl iodide; 2) NaOH; 3) H3O*; 4) A. Hint: Remember that B-oxo carboxylic undergo decarboxylation (loss of 1 equivalent of CO₂) when strongly heated. acids

Malonic ester synthesis 4. Write the reaction showing all intermediates when H₂C(CO₂Et)2 (diethyl malonate) is reacted with NaOEt followed by 1) ethyl iodide; 2) NaOH; 3) H3O*; 4) A. Hint: Remember that B-oxo carboxylic undergo decarboxylation (loss of 1 equivalent of CO₂) when strongly heated. acids

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

Give the major organic product for the following reaction
a) Put these three common types of carbonyl compound in order of decreasing reactivity ester amide acid chloride b) For the least reactive, show the interconversion to its other resonance form: How does this electron delocalisation make it stable? c) For the most reactive, draw the mechanism of its undergoing hydrolysis (reaction with H2O): Why makes this type of carbonyl so reactive to nucleophiles?
In the following acid-base reactions, 1. draw Lewis structures of the reactants and the products. 2. determine which species are acting as electrophiles (acids) and which are acting as nucleophiles (bases). 3. use the curved-arrow formalism to show the movement of electron pairs in these reactions, as well as the imaginary movement in the resonance hybrids of the products. 4. indicate which reactions are best termed Brønsted-Lowry acid-base reactions. (c) -BH₁₂ BH3 + CH3-O-CH3 → CH3-O-CH3 (d) 유 0- CH3-C H + -OH CH₁₂-C-H OH
Please answer each part A B and C
How is sodium enolate formed by adding NaOH to dimedone? What is the structure? Please include the actual structure, not just the formula, this is the part I am most confused about.
Draw the organic product of the Bronsted acid-base reaction. Include all lone pairs and charges as appropriate. Ignore any counterions. H3O+ Select to Draw H Z: H
Give typed full explanation not a single word hand written otherwise leave it
Explain why metal hydride reduction gives an endo alcohol as the major product in one reaction and an exo alcohol as the major product in the other reaction.
Which approach is SAFEST for the synthesis of the following ester: معه a. C. d. + CH₂OH b. ང་ཐིག་, - san ““ - OH ... + CH₂OH A OA OB ос OD + CH₂CH₂CH₂OH
9) a) Diagram the acid (H3O+) catalyzed enolizaton of acetaldehyde. . b) Diagram the base (OH-) catalyzed formation of cyclopentanone from its enol form.
Question 2 ?
Draw the major product of this reaction. Ignore inorganic byproducts. I I I I I I 1. Hg(Cl)2, CH3OH 2. NaBH4, NaOH Select to Edit OH Please select a drawing or reagent from the question area