By using only amide/Peptide bond forming rxn and a lkylation rxns. Provide all the reaction steps with the reagent needed and conditionswith out showing the mechanism for each step to form the product. Note: Use protecting groups like (Boc, Fmoc, and others) H¸NNHrxns.By using only amide / Peptide bond forming rxn and alkylationProvide all the reaction steps with the reagent needed and conditionsshowing the mechanism for each step to form the product.protecting groups. like (Boc, Fmoc, and others)with outNote: UseHNH₂N.-NH₂- +ΝΗ

The objective of this question is to plan and execute a sequence of reactions to achieve a target…

By using only amide/Peptide bond forming rxn and a IKylation rxns. Provide all the reaction steps with the reagent needed and conditions with out showing the mechanism for each step to form the product. Note: Use protecting groups like (Boc, Fmoc, and others) H₂NNH 2

By using only amide/Peptide bond forming rxn and a IKylation rxns. Provide all the reaction steps with the reagent needed and conditions with out showing the mechanism for each step to form the product. Note: Use protecting groups like (Boc, Fmoc, and others) H₂NNH 2

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Related questions

Q: In the reaction of a nitrile with a Grignard reagent, there are two steps: a) nucleophilic addition…

A: The Grignard reagent provides a nucleophile in the form of an alkyl group.

Q: The final major product of the following Edman reaction is CH3 NH₂ Ph Ph Ph ZH HO Ph—N=C Peptide HN…

A: we have to determine the product the given reaction

Q: Refer to the bar graph below, Explain why e.g. the n→π* interactions contribute more to the overall…

A: Proteins are complex molecules that are made up of long chains of amino acid residues. A linear…

Q: The rate constant for the uncatalyzed reaction of two molecules of glycine ethyl ester to form…

Q: 6. Good Question. DNA is a double helix made-up of a mixture of four bases (guanine, cytosine,…

A: The concept which can be used to answer this is that greater the number of interactions present…

Q: Prontosil is an antibacterial sulfa drug. Provide the intermediates, reagents, and product complete…

A: Prontosil is an antibacterial sulfa drug. Given is prontosil synthesis reaction.

Q: The following three derivatives of succinimide are anticonvulsants and have found use in the…

Q: Draw the product of the reaction shown below. Ignore inorganic byproducts. Na2Cr2O7 H2O, CH3CO₂H o

A: Benzylic oxidations:Alkyl groups adjacent on the benzylic position are oxidised to carboxylic with…

Q: Show the mechanism of the reaction of glucose with phenylhydrazine

A: Osazone is the final product of the reaction between glucose and phenyl hydrazine.

Q: HOOCCH,CH,COOH heat Select Draw Templates More Er 2 Q

A: When succinic acid is heated it forms Succinic anhydride

Q: Drag the appropriate labels to their respective targets. Labels can be used more than once. Reset…

A: Given molecule is peptide. Which formed by peptide bond . From alpha amino acids. Peptide bond is…

Q: WS-3.8: Draw the Newman projection/s for 3-aminobutan-2-ol, looking down the C2-C3 bond where there…

A: In the molecules are observed along the connection connecting the main carbon atoms, shown as…

Q: The start drug is Tolbutamide and the product is Chlorpropamide. Which of the following is…

A: The question appears to be related to the modification of a drug molecule, specifically the…

Q: Draw possible hydrogen bonds between the side chains physiological pH. 1. Asn and Ser 2. Thr, try 3.…

Q: 8. (a) Draw a mechanism for the following enzymatic reaction. .coo HS NH, "OOC. `NH3* `NH,* coo NH3*…

A: Cysteine is an amino acid having formula HOCCH2(NH)CH2SH. It undergoes enzymatic reaction to form…

Q: 1. How would you synthesize adenosine monophosphate from ribose. Your synt path should be based on…

A: TRPM2 (transient receptor potential cation channel, subfamily M, member 2) is a nonselective cation…

Q: Methionine enkephalin is a pentapeptide that is produced by the body to control pain. From the…

A: GivenN-terminus C-terminus…

Q: Glutathione can form a disulfide bridge with another glutathione molecule (GSSG) via radical…

A: Glutathione (GSH), an important antioxidant, is mainly comprised of three amino acids: glycine,…

Q: Glutamic acid is a naturally occurring α-amino acid that contains acarboxy group in its R group side…

A: a) At pH=1 , that is in highly acidic medium, the amino group gains a proton and thus the positive…

Q: 1. Molecule A below is a protected amino acid. Identify the correct amino acid. Alanine Proline…

A: The tyrosine side chain is protected. Derivatives with the side chain protected as the Bzl ether are…

Q: The thioester, which form when a Cys side chain condenses with a Gln side chain a few residues away,…

A: The objective of this question is to draw the resulting ester and amide when Cys (cysteine) reacted…

Q: H3C CH3 H3C CH3 NaN3 NaCI H3C CI H3C "N3

A: Here we have to write structure of initially formed tetrahedral intermediate formed when…

Q: Indicate if each is hydrophobic or hydrophilic. Drag the appropriate items to their respective bins.…

A: Given amino acids: Y, Met, aspartate, leucine

Q: (üi) -CH2 O Nucleotide base 80% aqueous →? ACOH 20 °C LOH NaOH (üi) →? (MeO)2SO2 (iv) NaOMe →? Ph

A: Hydrolysis of ether to give an acohols (MeO)2SO2 is used for methylating agent Cyclolactone cleave…

Q: While there are proposals to explain the formation of sugars and nucleic aci bases separately, the…

A: “Since you have posted a question with multiple sub-parts, we will solve the first three subparts…

Q: N Citalopram Capsaicin но HO HO Atropine Prostaglandin D2

A: Since you have asked a question with multiple sub-parts, we will solve first three sub-parts for…

Q: Under acidic conditions (such as in your stomach) benzyl penicillin (BP) breaks down to three…

Q: During acidosis of a protein, shown below, salt bridges are broken, resulting in denaturation.…

A: Acidosis is caused by the overproduction of acid that builds up in the blood or an excessive loss of…

Q: 1. Create a flowchart for the synthesis and purification of phenacetin. Draw out your steps for the…

A: Purification is the process of removing undesired contaminants from an organic product. The…

Q: You want to study the effect of lysine methylation on gene regulation. The lysine amino acid…

A: The objective of this question os to explain the lysine methylation on gene regulation. It mainly…

Q: lysozyme catalyzes the hydrolysis of a carbohydrate linkage in part of the bacterial wall. The…

A: We will be discuss a mechanism for above question.

Q: How do you synthesize the amino acid Phenylalanine from benzaldehyde as the starting compound?…

A: Following is the preparation of Phenylalanine from benzaldehyde.

Q: 2. In the synthesis of peptides, carboxylic acids are condensed with amines in the present of a…

A: The given question discusses about DCC assisted condensation of amine and carboxylic acid to form an…

Q: CH,OCH,CI SnCl, CH,CI The chloromethylated polystyrene resin used for Merrifield solid-phase peptide…

Q: The dynorphins are a group of opioid peptides that play an importantrole in changes in the brain…

A: Opioids are drugs that bind with the opioid receptor and produce effects like morphine; medically…

Q: This is a reaction scheme for epoxidation of cholesterol with MCPBA. The reaction mixture was put…

A: alumina acts as seperating agent . Burette is filled up with alumina. Then product mixture is put on…

Q: 7) Please show arrow pushing for the E1CB reaction to convert Serine to alpha Amino acrylate (an…

A: An arrow always depicts from a region of high electron density to low electron density ; that is…

Q: When aspirin is made from acetic acid, the by product is H2O; when acetic anhydride 1S used, the…

A: When aspirin is made from acetic acid, the by product is H2O when acetic anhydride 1S used, the…

Q: Bacteria have gain resistance to vancomycin, e.g. vancomycin resistant enteroccoci (VRE), by…

Q: Write out the steps needed to synthesize the following peptide using the Merrifield method.

A: Merrifield Method: In this method, the peptide is being produced by the removal of water from the C…

Q: There are 20 common, naturally occurring amino acids from which all proteins are derived (as will be…

Q: NH2 H2N-DNA- H -N-DNA- H H2N-DNA- H2N OCH3 H2N. HN-DNA H3C NH H3C "NH2 Mitomycin C DNA adduct…

A: Reaction mechanism: A chemical reaction occurs by the sequence of elementary steps is called…

Q: Consider the following reaction schemes involving the reaction of an imine with an organolithium…

A: We have find out the reaction of an imine with an organolithium compound.

Q: Draw/write out the peptide bond formation mechanism. Be sure to incorporate the group that acts as a…

A: A peptide bond is a covalent bond that links amino acids together in a protein chain. It forms…

Question

By using only amide/Peptide bond forming rxn and a lkylation rxns. Provide all the reaction steps with the reagent needed and conditions
with out showing the mechanism for each step to form the product. Note: Use protecting groups like (Boc, Fmoc, and others) H¸NNH
rxns.
By using only amide / Peptide bond forming rxn and alkylation
Provide all the reaction steps with the reagent needed and conditions
showing the mechanism for each step to form the product.
protecting groups. like (Boc, Fmoc, and others)
with out
Note: Use
HN
H₂N.
-NH₂- +
ΝΗ

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1: Define Protecting Group

VIEW

Step 2: Explain the reaction synthesis

VIEW

Step 3: Explain the final step synthesis

VIEW

Solution

VIEW

Step by step

Solved in 4 steps with 19 images

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.

Similar questions

One of the ways in which an L a-amino acid can be synthesized is to carry out an Sy2 reaction between an a-bromo acid and ammonia. (The wavy line indicates that the bond could be a dash or a wedge.) Draw the stereoisomer of the a-bromo acid that would be necessary Br. H3N. R An a-bromo acid An L a-amino acid to produce L-alanine, in which the R group is CH3.
13) Suggest and efficient synthesis for the following peptide with the given starting materials. Show all reagents and the major products formed after each step. An ideal synthesis will involve 4 steps. NH₂ OH NH₂ OH ??? NH3 OH
Describe a reaction mechanism that occurs to maleic anhydride when water is added.
Write what kind of reaction is each one of the four reactions depicted. (e.g. peptide bond formation, SN2 etc.) GLUCURONIC ACID SULPHATE CHCI, CHMO NO xox HO NO ON OSO, N 10, chloramphenicol: antibiotic prenalterol: B-blocker AMINO ACIDS MERCAPTURATES (Glutathione conjugates) CONHCH,COOH CH,CI OH ACNH COON OH ACNH ON ON YN COCK, CH.SCH,CHCOOK
Draw the mechanism of cyclization for the following aromatic polyketides (Note: please DRAW and show the process of cyclization, don't give an explanation in text.): 1. orsellinic acid 2. xanthoxylin 3. curvulinic acid 4. diaporthin 5. monocerin 6. griseofulvin 7. alternariol 8. endocrocin 9. curvularin 10. radiciciol 11. nalgiovensin
Provide an electron pushing mechanism for the conversion shown below. Abbreviate the enzyme catalyst active site groups (BH* and B:) as needed. Which purine base is used? NH₂ Enz H₂O 'N NH
In serine proteases, the oxygen of the hydroxyl group on serine is made more nucleophilic primarily by the side chain of a Asp. Tyr. Lys. Gly. His.
The Strecker reaction is a three component reaction (aldehyde/ketone, amine, and cyanide) used to synthesize amino acids. From the example below, what three reactions are occurring during the formation of phenylalanine? Provide mechanisms for the entire reaction sequence сно 1. NH3, HOAC NH2 2. KCN 3. HCI, H,0 phenylalanine
Draw the product that valine forms when it reacts with CH3COCl, pyridine; then H2O. You do not have to consider stereochemistry. Do not draw organic or inorganic by-products. Draw the product in neutral form unless conditions are clearly designed to give an ionic product. Include cationic counter-ions, e.g., Na+ in your answer, but draw them in their own sketcher. Do not include anionic counter-ions, e.g., I-, in your answer.
6. Which would be more appropriate as the reduction in the following sequence, a Clemmensen or a Wolff-Kishner? Explain. CHO 1. HOCH₂CH₂OH (1 eq), H* 2. reduction 3. H30* CHO 7. Which has the higher boiling point, 1-butanol or 1-butanamine?
Draw the product that valine forms when it reacts with di-tert-butyl dicarbonate and triethylamine followed by an aqueous acid wash. O • You do not have to consider stereochemistry. • Do not draw organic or inorganic by-products. • Draw the product in neutral form unless conditions are clearly designed to give an ionic product. • Include cationic counter-ions, e.g., Na+ in your answer, but draw them in their own sketcher. • Do not include anionic counter-ions, e.g., I, in your answer. 90.0 ChemDoodle /n [F
OCH3 + CH3NH2 a. Draw the structure of the tetrahedral intermediate INITIALLY-FORMED in the reaction shown. • • • You do not have to consider stereochemistry. Do not include counter-ions, e.g., Na+, I, in your answer. In cases where there is more than one answer, just draw one. √n [ ? ChemDoodle b. Draw the structures of the organic products of the acyl transfer reaction. • You do not have to consider stereochemistry. • Draw the neutral form of the products: no charges.