The 1992 drama film Lorenzo’s Oil is based on the true story of Lorenzo Odone, who was diagnosed with a hereditary orphan disease called adrenoleukodystrophy (ALD). His diagnosis induced his parents to research the disease intensively, interview scientists who had studied the disease, and convince a small pharmaceutical manufacturer in England to make a few doses of an experimental drug. Explain why there are so many more drugs available to treat acne than the typical orphan disease, and discuss any government efforts that benefit people afflicted by rare diseases.

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