o Suppose Gina climbs a high mountain where the oxygen partial pressure in the air decreases to 70 torr. Assume that the pH ofher tissues and lungs is 7.4 and the oxygen concentration in her tissues is 20 torr. The P50 of hemoglobin is 26 torr. The degreeof cooperativity of hemoglobin (n) is 2.8.Estimate the percentage of the oxygen-carrying capacity that she utilizes.oxygen-carrying capacity utilized:After Gina spends a day at the mountaintop, where the oxygen partial pressure is 70 torr, the concentration of2,3-bisphosphoglycerate (2,3-BPG) in her red blood cells increases.Why does increasing the concentration of 2,3-BPG in Gina's blood cells help her function well at high altitudes?The P50 value of her hemoglobin increases, promoting oxygen delivery to tissues.The P50 value of her hemoglobin decreases, causing more blood-to-tissue oxygen offloading.The extra 2,3-BPG stabilizes the relaxed, or R, state of hemoglobin, increasing oxygen binding.Excess 2,3-BPG binds oxygen when hemoglobin becomes saturated, acting as an additional oxygen transporter.%

Consider the following reaction: where P is the protein, L is the ligand, PL is the protein-ligand…

Answered: Suppose Gina climbs a high mountain…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Below is the O₂ binding curve for adult Hb in whole blood (containing BPG) shown in red (labelled Hb). Fraction of Hb bound with Oxygen 1.0 0.8 0.6 0.4 0.2 0.0 0 20 40 pO2 (torr) 60 80 ABC c. Which curve lacks cooperativity? [Select] Hb 100 a. Which curve is the best representation for stripped Hb (pure hemoglobin with heme, but no other small allosteric molecules associated)? [Select] b. Which curve has the lowest affinity (as measured by the p50)? [Select]
72.4.1
Draw three separate oxygen-hemoglobin dissociation curves and then use arrows to show the change in oxygen saturation of most hemoglobins when: 1. deoxygenated blood enters the capillaries in the lungs. 2. oxygenated blood enters the capillaries in muscle tissue at rest. 3. oxygenated blood enters the capillaries in muscle tissue during vigorous exercise.
At which temperature given does hemoglobin have a higher affinity for oxygen?
In Charles’ blood, the partial pressure of CO in the blood (0.4 mm Hg) is far lower than the partial pressure of O2, yet the percent saturation of hemoglobin by each gas is approximately equal. What does this tell you about the affinity of hemoglobin for CO?
Is the concerted or sequential model better at describing the cooperative binding of oxygen by hemoglobin?
Oxyhemoglobin formation is promoted at the while deoxyhemoglobin formation is promoted at the tissues). (lungs/ systemic tissues), (lung/ systemic the most important factor determining how much 02 binds to hemoglobin is the
Below are multiple oxygen binding affinity curves for hemoglobin. The affinity curve for normal hemoglobin in blood is represented by curve "D," at a pH of 7.2 and at a concentration of 5mM BPG and 26 mM CO2. O₂ saturation (%) 100 Answer 1: B Answer 2: [Select] Answer 3: B Answer 4: 80 A 60 1. How would changes to acidity, BPG concentration and CO₂ levels affect the binding affinity curve and p50? lower than Answer 5: E 40 1. BPG concentration is decreased to 3mM: The binding affinity curve would look like B. The p50 would be lower than normal (D). 2. pH is increased to 7.6: The binding affinity curve would look like B. The p50 would be [Select] normal (D). 20 3. CO₂ concentration is increased to 30 mM: The binding affinity curve would look like. [Select] The p50 would be Answer 6: 0 normal (D). II. The hemoglobin has been treated with a denaturing solution which disrupts quaternary structure only, and has a binding affinity resembling myoglobin. The binding affinity curve would look…
Why is the oxygen-hemoglobin dissociation curve so steep?
Use the respiratory rate values listed below to fill-in the empty boxes in the table below. Respiratory Rate values: 24.69 BPM and 10.04 BPM
Illustrate how the PaO2 and SaO2 can be very misleading and dangerous when the hemoglobin level is not entered into the patient’s oxygen transport calculations?
Carbon monoxide (CO) is a colorless, odorless gas produced during combustion of fuels (for example, by car engines and furnaces). The following graph depicts an oxygen dissociation curve in the absence and presence of varying amounts of carbon monoxide. Based on these results, in the presence of 20% CO, when PO2 is 90mmHg you should expect each hemoglobin molecule to have _____ molecule(s) of O2 bound a) 1 b) 2 c) 3 d) 4

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