Which of the folloqing statements about BPG and its effect on oxygen transport is NOT true?
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BPG binds more tightly to adult Hb than fetal Hb, thus facilitating the O2 transfer to the fetus. |
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An initial reponse in adapting to higher altitude is increased BPG synthesis in erythrocites. This increase in BPG concentraton will shift the Hb saturation curve to a higher affinity position relative to its sea-level position, facilitating better O2 aborption and transport at higher altitudes. |
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The presence of BPG in mammalian erythrocytes decreases Hb affinity for O2 |
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BPG binds Hb in its central cavity in the R-state but not in the T-state, and in this way decreasing Hb affinity for O2 |
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BPG binds Hb in its central cavity in the T-state but not in the R-state, and in this way decreasing Hb affinity for O2 |
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