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Self-splicing reaction G-binding site 3' CUCUCU p A AGGGAGGE Intron Exon Exon 5 PÇUÇUÇU-OH AG AGGGAGG G-OH AG PAGGGAGGE Linear intron 5 aCucucuu Spliced exons FIGURE 8-18 The self-splicing intron from Tetrahymena executes two transesterification reactions to excise itself from RNA. Reactions in exon splicing Intron но 5' O=P- O- Exon 1 5 Exon 2 First transesterification 5' 2' O-P-O -0-- 3' Second transesterification 5' 2 Spliced exons 3' он Excised lariat intron 0 = 3' oxygen of exon 1 0 = 2' oxygen of branch point A 0= 3' oxygen of intron FIGURE 8-17 Two transesterification reactions take place in the splicing of RNA: first, to join the 5' donor end of the intron to the internal branch point (first reaction in Figure 8-16) and, second, to join the two exons together (second reaction in Figure 8-16).

Self-splicing reaction G-binding site 3' CUCUCU p A AGGGAGGE Intron Exon Exon 5 PÇUÇUÇU-OH AG AGGGAGG G-OH AG PAGGGAGGE Linear intron 5 aCucucuu Spliced exons FIGURE 8-18 The self-splicing intron from Tetrahymena executes two transesterification reactions to excise itself from RNA. Reactions in exon splicing Intron но 5' O=P- O- Exon 1 5 Exon 2 First transesterification 5' 2' O-P-O -0-- 3' Second transesterification 5' 2 Spliced exons 3' он Excised lariat intron 0 = 3' oxygen of exon 1 0 = 2' oxygen of branch point A 0= 3' oxygen of intron FIGURE 8-17 Two transesterification reactions take place in the splicing of RNA: first, to join the 5' donor end of the intron to the internal branch point (first reaction in Figure 8-16) and, second, to join the two exons together (second reaction in Figure 8-16).

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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By comparing Figures 8-16 and 8-17 with Figure 8-18,
speculate what features of RNA permit self-splicing (that
is, in the absence of proteins)

Self-splicing reaction G-binding site 3' CUCUCU p A AGGGAGGE Intron Exon Exon 5 PÇUÇUÇU-OH AG AGGGAGG G-OH AG PAGGGAGGE Linear intron 5 aCucucuu Spliced exons FIGURE 8-18 The self-splicing intron from Tetrahymena executes two transesterification reactions to excise itself from RNA.
Transcribed Image Text:Self-splicing reaction G-binding site 3' CUCUCU p A AGGGAGGE Intron Exon Exon 5 PÇUÇUÇU-OH AG AGGGAGG G-OH AG PAGGGAGGE Linear intron 5 aCucucuu Spliced exons FIGURE 8-18 The self-splicing intron from Tetrahymena executes two transesterification reactions to excise itself from RNA.
Reactions in exon splicing Intron но 5' O=P- O- Exon 1 5 Exon 2 First transesterification 5' 2' O-P-O -0-- 3' Second transesterification 5' 2 Spliced exons 3' он Excised lariat intron 0 = 3' oxygen of exon 1 0 = 2' oxygen of branch point A 0= 3' oxygen of intron FIGURE 8-17 Two transesterification reactions take place in the splicing of RNA: first, to join the 5' donor end of the intron to the internal branch point (first reaction in Figure 8-16) and, second, to join the two exons together (second reaction in Figure 8-16).
Transcribed Image Text:Reactions in exon splicing Intron но 5' O=P- O- Exon 1 5 Exon 2 First transesterification 5' 2' O-P-O -0-- 3' Second transesterification 5' 2 Spliced exons 3' он Excised lariat intron 0 = 3' oxygen of exon 1 0 = 2' oxygen of branch point A 0= 3' oxygen of intron FIGURE 8-17 Two transesterification reactions take place in the splicing of RNA: first, to join the 5' donor end of the intron to the internal branch point (first reaction in Figure 8-16) and, second, to join the two exons together (second reaction in Figure 8-16).
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