Select the chemical consequences that could contribute to DNA instability at AP sites.fewer hydrogen bonds between the unpaired pyrimidine base and waterdisruption of the base-stacking interactionsincreased ability of the deoxyribose ring to open without the attachment of the purine basedecreased interaction between the mutated DNA strand and histones Hydrolysis of the N-glycosyl bond between deoxyribose and apurine base in DNA creates an apurinic (AP) site. An AP site ismore thermodynamically destabilizing to a DNA moleculethan is a mismatched base pair.Examine the structure of an AP site.HNH₂N N0Guanine-O-P-O-CH₂O.H₂NHHNHH HHodHofo-0-Guanosine residue(in DNA)-0-CH₂HH HApurinic residueHOHH

AP sites are apuraniya sites that are created through the hydrolysis of N glycosyl bond between…

Answered: Select the chemical consequences that…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Similar questions

Explain how DNA-binding proteins can make sequence-specific contacts to a double-stranded DNA molecule without breaking the hydrogen bonds that hold the bases together. indicate how, through such contacts, a protein can distinguish a T-A from a C-G pair. indicate the parts of the nucleotide base pairs that could form noncovalent interactions— hydrogen bonds, electrostatic attractions, or hydrophobic interactions -with a DNA-binding protein.
Many thanks
Explain how mismatch repair fixes incorrectly matched base pairs.
Explain how the chemical structure ofdeoxynucleotides determines the orientation of theDNA strands and how this affects the direction of DNAsynthesis.
. It is thought that the signal for eukaryotic mismatch repair, for iden- tifying the strand to be repaired, could be nicks in the DNA to be repaired. If so, would you expect the nicked strand or the intact strand to be the strand to be repaired? Briefly explain your answer.
Given the following sequence of a coding DNA strand: AGTTGCGCATGCCAGAGAGGTTCGAGTGCACATAACTTGAG The template DNA strand will have the following sequence written in the conventional manner with no orientation indicators: The corresponding tRNA sequence written in the conventional manner with no orientation indicators will be: After translation was complete, the resulting polypeptide underwent post-translational modification wherein the N-terminal Met residue was removed from the polypeptide. Using one-letter abbreviations, the sequence of the resulting polypeptide is
Replication in eukaryotes begins at the OriC sequence. This particular sequence is characterized by (select the correct statements): A-T rich and therefore energetically more favourable to localy unwind DNA. Contains the DnaA boxes. Recruits histone acetyltransferases. Is locally unwound by DnaA, HU and IHF proteins. QUESTION 16 The Single Strand-binding proteins (SSBS) in prokaryotes and the Replication Protein A (RPA) in eukaryotes are functionally equivalent. Their role in the DNA replication process is to (select the correct statement): Stabilize the single stranded DNA structure after unwinding by the DNA helicase. Recruit the general transcription factors to the promoter. Relieve the torsional stress ahead of the replication fork. Induce double strand breaks. O O O O O O O
Where do you predict the N- and C-termini are located for Max? Match the words in the left column to the appropriate blanks in the sentences on the right. electrostatic dispersion negative C-terminus positive positively negatively N-terminus The Reset Help is interacting with the DNA. The first reason for this is because the a-amino group is positively charged and will interact favorably with the of the charge on the phosphodiester backbone of the DNA. The second reason is that this orientation also situates the partial end of the helical macrodipole for favorable interactions with the charged phosphodiester backbone of the DNA
Write down the major differences between DNA and RNA.keeping in mind the concept of "central dogma". Explain whether the information from protien is transfered to DNA? If yes/No, explain.
Proflavine was used to treat wounded soldiers in the Far East during the second world war. Which of the following statements is false regarding proflavine! H₂N7 NH₂ Its target is located in the cell membrane. Its planar shape is important to intercalation. The primary amine groups are protonated and interact with phosphate groups of the DNA backbone. When inserted into DNA, the tricyclic system can form van der Waals interactions with base pairs above and below it.
One of the original structures proposed for DNA had all the phosphate groups positioned at the center of a long fiber. Give a reason why this proposal was rejected
Give 3 strand slippage and trinucleotide repeat disorder examples

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