Select the chemical consequences that could contribute to DNA instability at AP sites.fewer hydrogen bonds between the unpaired pyrimidine base and waterdisruption of the base-stacking interactionsincreased ability of the deoxyribose ring to open without the attachment of the purine basedecreased interaction between the mutated DNA strand and histones Hydrolysis of the N-glycosyl bond between deoxyribose and apurine base in DNA creates an apurinic (AP) site. An AP site ismore thermodynamically destabilizing to a DNA moleculethan is a mismatched base pair.Examine the structure of an AP site.HNH₂N N0Guanine-O-P-O-CH₂O.H₂NHHNHH HHodHofo-0-Guanosine residue(in DNA)-0-CH₂HH HApurinic residueHOHH

AP sites are apuraniya sites that are created through the hydrolysis of N glycosyl bond between…

Answered: Select the chemical consequences that…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Explain how mismatch repair fixes incorrectly matched base pairs.
Replication in eukaryotes begins at the OriC sequence. This particular sequence is characterized by (select the correct statements): A-T rich and therefore energetically more favourable to localy unwind DNA. Contains the DnaA boxes. Recruits histone acetyltransferases. Is locally unwound by DnaA, HU and IHF proteins. QUESTION 16 The Single Strand-binding proteins (SSBS) in prokaryotes and the Replication Protein A (RPA) in eukaryotes are functionally equivalent. Their role in the DNA replication process is to (select the correct statement): Stabilize the single stranded DNA structure after unwinding by the DNA helicase. Recruit the general transcription factors to the promoter. Relieve the torsional stress ahead of the replication fork. Induce double strand breaks. O O O O O O O
Where do you predict the N- and C-termini are located for Max? Match the words in the left column to the appropriate blanks in the sentences on the right. electrostatic dispersion negative C-terminus positive positively negatively N-terminus The Reset Help is interacting with the DNA. The first reason for this is because the a-amino group is positively charged and will interact favorably with the of the charge on the phosphodiester backbone of the DNA. The second reason is that this orientation also situates the partial end of the helical macrodipole for favorable interactions with the charged phosphodiester backbone of the DNA
Proflavine was used to treat wounded soldiers in the Far East during the second world war. Which of the following statements is false regarding proflavine! H₂N7 NH₂ Its target is located in the cell membrane. Its planar shape is important to intercalation. The primary amine groups are protonated and interact with phosphate groups of the DNA backbone. When inserted into DNA, the tricyclic system can form van der Waals interactions with base pairs above and below it.
Give 3 strand slippage and trinucleotide repeat disorder examples
DNA polymerase occasionally incorporates the wrong nucleotide during DNA replication. If left unrepaired, the base-pair mismatch that results will lead to mutation in the next replication. As part of a template strand, the incorporated wrong base will direct the incorporation of a base complementary to itself, so the bases on both strands of the DNA at that position will now be different from what they were before the mismatch event. The MER-minus strain of yeast does not have a functional mismatch excision repair system, but it has normal base excision repair and nucleotide excision repair systems. Which of the following statements is correct about differences in the mutation spectrum between MER-minus and wildtype yeast? More than one answer is correct. Options: More point mutations will arise in MER-minus yeast. Fewer point mutations will arise in MER-minus yeast as compared with wildtype. Of the total point mutations that…
Polyglycine, a simple polypeptide, can form a helix with φ = -80°, ψ = +150°. From the Ramachandran plot (as shown), describe this helix with respect to handedness.
Within living cells, many different proteins play importantfunctional roles by binding to DNA. Some proteins bind to DNA butnot in a sequence-specific manner. For example, histones are proteinsimportant in the formation of chromosome structure. The positivelycharged histone proteins bind to the negatively charged phosphategroups in DNA. In addition, several other proteins interact with DNAbut do not require a specific nucleotide sequence to carry out theirfunction. For example, DNA polymerase, which catalyzes thesynthesis of new DNA strands, does not bind to DNA in a sequencedependentmanner. By comparison, many other proteins do interactwith nucleic acids in a sequence-dependent fashion. This means that a specific sequence of bases can provide a structure that isrecognized by a particular protein.Someexamples include transcription factors that affect the rate oftranscription and proteins that bind to origins of replication inbacteria.What topic in genetics does this question address?
How are deoxyribonucleoside triphosphates (precursors of daughter DNA strands) and ribonucleoside triphosphates (precursors of RNA strand) differ from each other?
, describe the normal role of the component, and choose from the selection the most direct effect of the mutation and explain WHY. Choose from the 4 following effects: Initiation of DNA synthesis okazaki fragment synthesis Leading strand elongation lagging-strand completion --> Explain why these mutant strains are most likely temperature-sensitive mutants
If the following nucleotide sequence, CTC/TGT/AAG/ACC/TTT experienced a mutation resulting in the deletion of the second cytosine in the first DNA triplet so the sequence is now CT_/TGT/AAG/ACC/TTT, what would be the amino acid sequence created from this mutated DNA strand? Table of mRNA codons UUA, UUG = leucine AGG, AGA = arginine %3D CAU, CAC = histidine GUU, GÜC, GUA = valine GAA. GAG=glutamic acid GCU, GUA, GUG = alanine GAU, GAC = asparagine GGU, GGC, GGA = glycine UCA, UCU =serine CGU, CGC, CGA = arginine
, describe the normal role of the component, and choose from the selection the most direct effect of the mutation and explain WHY. Choose from the 4 following effects: Initiation of DNA synthesis okazaki fragment synthesis Leading strand elongation lagging-strand completion --> Extracts from a strain of bacteria lacking the 5’ to 3’ exonuclease activity of DNA polymerase

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