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S-adenosyl methionine (SAMe), a naturally occurring molecule found throughout the body, has been used as an antidepressant with some success. It has been available commercially in Europe since the late 1970s and is now available over-the-counter in the United States. Participants in the current study were 73 individuals with major depressive disorder who had not responded to a standard treatment using serotonin reuptake inhibitors (SRI) to relieve their symptoms. The effect of augmenting their SRI treatment with SAMe was investigated. George I. Papakostas et al., "S-Adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: A double-blind, randomized clinical trial," American Journal of Psychiatry, 167 (2010), pp. 942-948. bo The study was a randomized, double-blind trial conducted over six weeks, with 34 participants receiving a placebo (dummy pills) and the remaining 39 receiving pills containing SAMe (a trial is a medical experiment using actual patients as subjects). Macmillan Learning Explain why it is important to have a placebo group rather than having all participants receive pills containing SAMe. A placebo group is important so that each member of the placebo group can be matched with a member of the SAMe group and their results directly compared with each other. It is important to have a placebo group so that the experimenters do not know who is receiving which treatment. OIt would be too expensive to give all participants SAMe pills. Even though placebos possess no medical properties, some subjects may show improvement or benefits just as a result of participating in the experiment. The placebos allow those doing the

S-adenosyl methionine (SAMe), a naturally occurring molecule found throughout the body, has been used as an antidepressant with some success. It has been available commercially in Europe since the late 1970s and is now available over-the-counter in the United States. Participants in the current study were 73 individuals with major depressive disorder who had not responded to a standard treatment using serotonin reuptake inhibitors (SRI) to relieve their symptoms. The effect of augmenting their SRI treatment with SAMe was investigated. George I. Papakostas et al., "S-Adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: A double-blind, randomized clinical trial," American Journal of Psychiatry, 167 (2010), pp. 942-948. bo The study was a randomized, double-blind trial conducted over six weeks, with 34 participants receiving a placebo (dummy pills) and the remaining 39 receiving pills containing SAMe (a trial is a medical experiment using actual patients as subjects). Macmillan Learning Explain why it is important to have a placebo group rather than having all participants receive pills containing SAMe. A placebo group is important so that each member of the placebo group can be matched with a member of the SAMe group and their results directly compared with each other. It is important to have a placebo group so that the experimenters do not know who is receiving which treatment. OIt would be too expensive to give all participants SAMe pills. Even though placebos possess no medical properties, some subjects may show improvement or benefits just as a result of participating in the experiment. The placebos allow those doing the

MATLAB: An Introduction with Applications
MATLAB: An Introduction with Applications
6th Edition
ISBN:9781119256830
Author:Amos Gilat
Publisher:Amos Gilat
Chapter1: Starting With Matlab
Section: Chapter Questions
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S-adenosyl methionine (SAMe), a naturally occurring molecule found throughout the body, has been used as an antidepressant with some success. It has been available commercially in Europe since the late 1970s and is now available over-the-counter in the United States. Participants in the current study were 73 individuals with major depressive disorder who had not responded to a standard treatment using serotonin reuptake inhibitors (SRI) to relieve their symptoms. The effect of augmenting their SRI treatment with SAMe was investigated. George I. Papakostas et al., "S-Adenosyl methionine (SAM) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: A double-blind, randomized clinical trial," American Journal of Psychiatry, 167 (2010), pp. 942-948. O Macmillan Learning The study was a randomized, double-blind trial conducted over six weeks, with 34 participants receiving a placebo (dummy pills) and the remaining 39 receiving pills containing SAMe (a trial is a medical experiment using actual patients as subjects). Explain why it is important to have a placebo group rather than having all participants receive pills containing SAMe. A placebo group is important so that each member of the placebo group can be matched with a member of the SAMe group and their results directly compared with each other. It is important to have a placebo group so that the experimenters do not know who is receiving which treatment. OIt would be too expensive to give all participants SAMe pills. O Even though placebos possess no medical properties, some subjects may show improvement or benefits just as a result of participating in the experiment. The placebos allow those doing the
Transcribed Image Text:S-adenosyl methionine (SAMe), a naturally occurring molecule found throughout the body, has been used as an antidepressant with some success. It has been available commercially in Europe since the late 1970s and is now available over-the-counter in the United States. Participants in the current study were 73 individuals with major depressive disorder who had not responded to a standard treatment using serotonin reuptake inhibitors (SRI) to relieve their symptoms. The effect of augmenting their SRI treatment with SAMe was investigated. George I. Papakostas et al., "S-Adenosyl methionine (SAM) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: A double-blind, randomized clinical trial," American Journal of Psychiatry, 167 (2010), pp. 942-948. O Macmillan Learning The study was a randomized, double-blind trial conducted over six weeks, with 34 participants receiving a placebo (dummy pills) and the remaining 39 receiving pills containing SAMe (a trial is a medical experiment using actual patients as subjects). Explain why it is important to have a placebo group rather than having all participants receive pills containing SAMe. A placebo group is important so that each member of the placebo group can be matched with a member of the SAMe group and their results directly compared with each other. It is important to have a placebo group so that the experimenters do not know who is receiving which treatment. OIt would be too expensive to give all participants SAMe pills. O Even though placebos possess no medical properties, some subjects may show improvement or benefits just as a result of participating in the experiment. The placebos allow those doing the
Randomized Answer Bank Patients were randomly assigned to receive either SAMe or a placebo. Patients were randomly chosen to receive the SAMe pill, the placebo pill, or no pill. The treatment assigned to a patient was unknown to the patient but known to those responsible for assessing the effectiveness of that treatment. Patients were randomly assigned to either the placebo group or the double-blind group. The patients did not know that they were participating in a study. Double-blind The treatment assigned to a patient was unknown to both the patient and to those responsible for assessing the effectiveness of that treatment.
Transcribed Image Text:Randomized Answer Bank Patients were randomly assigned to receive either SAMe or a placebo. Patients were randomly chosen to receive the SAMe pill, the placebo pill, or no pill. The treatment assigned to a patient was unknown to the patient but known to those responsible for assessing the effectiveness of that treatment. Patients were randomly assigned to either the placebo group or the double-blind group. The patients did not know that they were participating in a study. Double-blind The treatment assigned to a patient was unknown to both the patient and to those responsible for assessing the effectiveness of that treatment.
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