Role of the triacyl glycerol cycle. Summarize the cycle referring to the figure. What role does the cycle play in metabolism?

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question

Role of the triacyl glycerol cycle. Summarize the cycle referring to the figure. What role does the cycle play in metabolism? Please be detailed in your answer

CO₂ +
+
Oxaloacetate → Pyruvate H₂O
Kidneys
a-Ketoglutarate Glucose -
NH₂
Excreted
Amino
acids
- Urea
Glycogen
Urea +
Amino
acids
Protein
Cori cycle
Alanine-glucose
cycle
Lactate
Amino
acids
1
Protein Glucose
2
Glucose
ATP
►
MA
→Pyruvate
7
Lactate Dihydroxyacetone
phosphate
Brain
Glycerol-3-P
Glycerol
5
Fatty acid
Pyruvate Acetyl-CoA
Glycogen
Liver
Acetyl-CoA
Pyruvate
Glucose
Ketone
bodies
Acetyl-CoA
ATP
Fatty acid
Triacylglycerol
LpL
Triacylglycerol
cycle
-Glycerol+
Skeletal
muscle
CO, + HO
LpL
3
Glucose
Pyruvate
Acetyl-CoA.
Fatty acid
Heart
LpL
Glycerol
Glucose
ATP
Dihydroxyacetone
phosphate
Glycerol-3-P
Glycerol
CO₂
+
H₂O
Adipose
tissue
Fatty acid Triacylglycerol
Figure 19.9 The flux of metabolites between major
tissues in the human body under normal homeostatic
conditions is shown. The liver serves as the metabolic
hub of the body and coordinates the exchange of
metabolites between major tissues and organs. Glucose
and triacylglycerols are the primary export products of tl
liver under normal physiologic conditions and are used a
sources of energy for oxidative phosphorylation in most
tissues. Triacylglycerols in the blood are hydrolyzed by
the enzyme lipoprotein lipase (LpL) on the surface of
endothelial tissue to release free fatty acids and glycerol
into nearby tissues as shown here. Amino acids, ketone
bodies, and lactate are usually found at relatively low
levels in the blood, but they can be very important
metabolites at times of limited food availability or intens
physical activity. See the text for details about the six
enumerated functions that are required to maintain
metabolic homeostasis.
Transcribed Image Text:CO₂ + + Oxaloacetate → Pyruvate H₂O Kidneys a-Ketoglutarate Glucose - NH₂ Excreted Amino acids - Urea Glycogen Urea + Amino acids Protein Cori cycle Alanine-glucose cycle Lactate Amino acids 1 Protein Glucose 2 Glucose ATP ► MA →Pyruvate 7 Lactate Dihydroxyacetone phosphate Brain Glycerol-3-P Glycerol 5 Fatty acid Pyruvate Acetyl-CoA Glycogen Liver Acetyl-CoA Pyruvate Glucose Ketone bodies Acetyl-CoA ATP Fatty acid Triacylglycerol LpL Triacylglycerol cycle -Glycerol+ Skeletal muscle CO, + HO LpL 3 Glucose Pyruvate Acetyl-CoA. Fatty acid Heart LpL Glycerol Glucose ATP Dihydroxyacetone phosphate Glycerol-3-P Glycerol CO₂ + H₂O Adipose tissue Fatty acid Triacylglycerol Figure 19.9 The flux of metabolites between major tissues in the human body under normal homeostatic conditions is shown. The liver serves as the metabolic hub of the body and coordinates the exchange of metabolites between major tissues and organs. Glucose and triacylglycerols are the primary export products of tl liver under normal physiologic conditions and are used a sources of energy for oxidative phosphorylation in most tissues. Triacylglycerols in the blood are hydrolyzed by the enzyme lipoprotein lipase (LpL) on the surface of endothelial tissue to release free fatty acids and glycerol into nearby tissues as shown here. Amino acids, ketone bodies, and lactate are usually found at relatively low levels in the blood, but they can be very important metabolites at times of limited food availability or intens physical activity. See the text for details about the six enumerated functions that are required to maintain metabolic homeostasis.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 3 steps

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON