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Please help fill out the metabolic Pathway table of Glycolysis and Pentose-Phosphate Pathway

Please help fill out the metabolic Pathway table of Glycolysis and Pentose-Phosphate Pathway

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Please help fill out the metabolic Pathway table of Glycolysis and Pentose-Phosphate Pathway

 

 
Pentose-Phosphate Pathway EC Reaction Glucose-6-phosphate dehydrogenase 1.1.1.49 Glucose-6-phosphate → 6-Phosphogluconolactone Enzyme gluconoactonase ribulose-5-phosphate isomerase ribulose-5-phosphate 3-epimerase Transketolase Transaldolase 3.1.1.17 5.3.1.6 5.1.3.1 2.2.1.1 2.2.1.2 AG (kJ/mol) -24.77 NADP Cofactors Regulation G6PD is affected by the ratio NADPH + H Notes G6PD is the only source of NADPH in erythrocytes/ G6PD deficiency leads to hemolysis /NADP*. With low [NADPH + H] the enzyme activity increases. Positive regulators: Insulin, Vit D, PI3-kinase, etc. Negative regulators: Aldosterone, arachidonic acid, CAMP, p53, etc. when the body is exposed to certain foods, drugs, infections, or stress. Symptoms may include dark urine, fatigue, paleness, rapid heart rate, and jaundice. G6PD deficiency is inherited in an X-linked recessive (Stanton, 2012)
Transcribed Image Text:Pentose-Phosphate Pathway EC Reaction Glucose-6-phosphate dehydrogenase 1.1.1.49 Glucose-6-phosphate → 6-Phosphogluconolactone Enzyme gluconoactonase ribulose-5-phosphate isomerase ribulose-5-phosphate 3-epimerase Transketolase Transaldolase 3.1.1.17 5.3.1.6 5.1.3.1 2.2.1.1 2.2.1.2 AG (kJ/mol) -24.77 NADP Cofactors Regulation G6PD is affected by the ratio NADPH + H Notes G6PD is the only source of NADPH in erythrocytes/ G6PD deficiency leads to hemolysis /NADP*. With low [NADPH + H] the enzyme activity increases. Positive regulators: Insulin, Vit D, PI3-kinase, etc. Negative regulators: Aldosterone, arachidonic acid, CAMP, p53, etc. when the body is exposed to certain foods, drugs, infections, or stress. Symptoms may include dark urine, fatigue, paleness, rapid heart rate, and jaundice. G6PD deficiency is inherited in an X-linked recessive (Stanton, 2012)
isent rows il necessary Glycolysis Hexokinase Phosphoglucose Isomerase Phosphofructokinase-1 Aldlase Enzyme Triosephosphate kinase Glyceraldehyde 3- phosphate dehydrogenase Phosphoglyceromutase Enolase Phosphoglyceromutase Pyruvaate kinase EC 2.7.1.1 5.3.1.9 1.11 2.13 5.3.1.1 1.2.1.12 5.4.2.11 4.2.1.11 5.4.2.12 2.7.1.40 Reaction Glucose + ATP- G6P + ADP 16.6 D-Glucose+ 6 phosphate - D 1.7 fructose 6 phosphate ΔG" (kJ/mol) fructose-6-phosphate - ADP + fructose dihydroxyaceton fructose 1,6 -biphosphate - 22.8 phosphate and glyceraldehyde 3-phosphate Dihydroxyaceton phosphate 7.9 -glyceraldehyde 3- phosphate. 3-phosphoglycerate-2- phosphoglycerate -13.7 glyceraldehyde-1,3 bis 6.3 phosphoglycerate 3 phosphate glucose two 3-carbon molecules -18.8 +/- 10 3-phosphoglycerate-2- phosphoglycerate Phosphoenolpyruvate + ADP-31.7 → Pyruvate + ATP 4.8 Cofactors Magnesium Mn2+ Callcium, Magnesium Magnesium don't require cofactors NAD+, NADP+ Magnesium Magnesium Magnesium K, Mg Regulation Allosteric effects (e.g. fructose-1,6- bisphosphate), phosphorylation on Ser12. Notes Pyruvate kinase deficiency (PKD) i a rare genetic disorder characterized by the premature destruction of red bloods, which is called hemolytic anemia.
Transcribed Image Text:isent rows il necessary Glycolysis Hexokinase Phosphoglucose Isomerase Phosphofructokinase-1 Aldlase Enzyme Triosephosphate kinase Glyceraldehyde 3- phosphate dehydrogenase Phosphoglyceromutase Enolase Phosphoglyceromutase Pyruvaate kinase EC 2.7.1.1 5.3.1.9 1.11 2.13 5.3.1.1 1.2.1.12 5.4.2.11 4.2.1.11 5.4.2.12 2.7.1.40 Reaction Glucose + ATP- G6P + ADP 16.6 D-Glucose+ 6 phosphate - D 1.7 fructose 6 phosphate ΔG" (kJ/mol) fructose-6-phosphate - ADP + fructose dihydroxyaceton fructose 1,6 -biphosphate - 22.8 phosphate and glyceraldehyde 3-phosphate Dihydroxyaceton phosphate 7.9 -glyceraldehyde 3- phosphate. 3-phosphoglycerate-2- phosphoglycerate -13.7 glyceraldehyde-1,3 bis 6.3 phosphoglycerate 3 phosphate glucose two 3-carbon molecules -18.8 +/- 10 3-phosphoglycerate-2- phosphoglycerate Phosphoenolpyruvate + ADP-31.7 → Pyruvate + ATP 4.8 Cofactors Magnesium Mn2+ Callcium, Magnesium Magnesium don't require cofactors NAD+, NADP+ Magnesium Magnesium Magnesium K, Mg Regulation Allosteric effects (e.g. fructose-1,6- bisphosphate), phosphorylation on Ser12. Notes Pyruvate kinase deficiency (PKD) i a rare genetic disorder characterized by the premature destruction of red bloods, which is called hemolytic anemia.
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