Recombination signal sequences are conserved heptamer and nonamer sequences that flank the V, J, and D gene segments which undergo recombination to generate the final V region coding exon. Some of these have 12-nucleotide spacers between the heptamer and nonamer, and others have 23-nucleotide spacers. The reason recombination signal sequences come in these two forms is:To ensure the correct assembly of gene segments so that a VH recombines to a DH and not to another VH, for instanceTo ensure that the heptamer and nonamer are found on the same face of the DNA double helixTo ensure that alpha, lambda, and heavy chains recombine within a locus and not between lociTo ensure that alpha, lambda, and heavy chain gene segments do not undergo recombination with non-immunoglobulin genesTo ensure that the RAG recombinase cuts the DNA between the last nucleotide of the heptamer and the coding sequence

Introduction: RAG 1 & 2 are the recombination activating genes that encode a portion of a…

Answered: Recombination signal sequences are…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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Recombination signal sequences are conserved heptamer and nonamer sequences that flank the V, J, and D gene segments which undergo recombination to generate the final V region coding exon. Some of these have 12-nucleotide spacers between the heptamer and nonamer, and others have 23-nucleotide spacers. The reason recombination signal sequences come in these two forms is:

To ensure the correct assembly of gene segments so that a V_H recombines to a D_H and not to another V_H, for instance
To ensure that the heptamer and nonamer are found on the same face of the DNA double helix
To ensure that alpha, lambda, and heavy chains recombine within a locus and not between loci
To ensure that alpha, lambda, and heavy chain gene segments do not undergo recombination with non-immunoglobulin genes
To ensure that the RAG recombinase cuts the DNA between the last nucleotide of the heptamer and the coding sequence

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