Rank the following DNA changes in order from least likely to change a phenotype to most likely to change a phenotype. Explain your ranking. A. A C → T change in an exon that results in an amino acid change in the resulting protein from alanine to valine (a conservative change) B. A C → T change in an exon that does not result in an amino acid change but introduces a new splice site C. A 2 bp insertion in the 3rd to last codon of a gene D. An expansion of a CGG repeat in the promoter of a gene from 50 copies to 200 copies E. A duplication of an entire gene
Gene Interactions
When the expression of a single trait is influenced by two or more different non-allelic genes, it is termed as genetic interaction. According to Mendel's law of inheritance, each gene functions in its own way and does not depend on the function of another gene, i.e., a single gene controls each of seven characteristics considered, but the complex contribution of many different genes determine many traits of an organism.
Gene Expression
Gene expression is a process by which the instructions present in deoxyribonucleic acid (DNA) are converted into useful molecules such as proteins, and functional messenger ribonucleic (mRNA) molecules in the case of non-protein-coding genes.
Rank the following DNA changes in order from least likely to change a
A. A C → T change in an exon that results in an amino acid change in the resulting protein from alanine to valine (a conservative change)
B. A C → T change in an exon that does not result in an amino acid change but introduces a new splice site
C. A 2 bp insertion in the 3rd to last codon of a gene
D. An expansion of a CGG repeat in the promoter of a gene from 50 copies to 200 copies
E. A duplication of an entire gene
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