Radiopaque imaging agents are substances administered either orally or intrave- nously that absorb X-rays more strongly than body material. One of the best known of these is barium sulfate, the key ingredient in the so-called barium cocktail for imaging of the gastrointestinal tract. Among other X-ray contrast media are the so- called triiodoaromatics. You can get some idea of the imaging for which they are used from the following selection of trade names: Angiografin, Gastrografin, Cardiografin, Cholegrafin, Renografin, and Urografin. Following is a synthesis for diatrizoic acid from benzoic acid. СООН COOH COOH NO2 (3) NO2 O,N COOH COOH СООН I ICI 4 NH2 H,N NH2 H,N 'N' `N' I I H H Diatrizoic acid

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Chapter1: Chemical Foundations
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Iodine monochloride, ICl, a black crystalline solid with an mp of 27.2°C and a bp of 97°C, is prepared by mixing equimolar amounts of I2 and Cl2. Propose a mechanism for the iodination of 3-aminobenzoic acid by this reagent.

Radiopaque imaging agents are substances administered either orally or intrave-
nously that absorb X-rays more strongly than body material. One of the best known
of these is barium sulfate, the key ingredient in the so-called barium cocktail for
imaging of the gastrointestinal tract. Among other X-ray contrast media are the so-
called triiodoaromatics. You can get some idea of the imaging for which they are used
from the following selection of trade names: Angiografin, Gastrografin, Cardiografin,
Cholegrafin, Renografin, and Urografin. Following is a synthesis for diatrizoic acid
from benzoic acid.
СООН
COOH
COOH
NO2
(3)
NO2
O,N
COOH
COOH
СООН
I
ICI
4
NH2
H,N
NH2
H,N
'N'
`N'
I
I
H
H
Diatrizoic acid
Transcribed Image Text:Radiopaque imaging agents are substances administered either orally or intrave- nously that absorb X-rays more strongly than body material. One of the best known of these is barium sulfate, the key ingredient in the so-called barium cocktail for imaging of the gastrointestinal tract. Among other X-ray contrast media are the so- called triiodoaromatics. You can get some idea of the imaging for which they are used from the following selection of trade names: Angiografin, Gastrografin, Cardiografin, Cholegrafin, Renografin, and Urografin. Following is a synthesis for diatrizoic acid from benzoic acid. СООН COOH COOH NO2 (3) NO2 O,N COOH COOH СООН I ICI 4 NH2 H,N NH2 H,N 'N' `N' I I H H Diatrizoic acid
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