The following reaction is showing production of ester using esterification reaction of n-butanol with acetic acid. OH + CH3CO₂H + H₂O Typical procedure of this reaction: 37g butanol, 60g glacial acetic acid and 3drops of sulphuric acid (H2SO4) are mixed together. The reaction mixture is then poured into 250cm³ water. The organic layer is separated and washed again with water (100cm³), saturated NaHCO3 (25cm³) and more water (25cm³). The crude ester is then dried over anhydrous Na2SO4 (5g), and then distilled. The yield=40g (69%). MW: C=12 gmot', O=16 gmot¹, H=1 gmot¹ a) Estimate the atom economy of this reaction b) Calculate the amount of waste and E-factor for this reaction c) Compute the effective mass yield for this reaction. d) Estimate the reaction mass efficiency. e) Critically comment why there is discrepancy in the value for yield, E-factor, atom economy, reaction mass efficiency and effective mass yield. Which one do you suggest the best to represent the greenness state of this reaction.
The following reaction is showing production of ester using esterification reaction of n-butanol with acetic acid. OH + CH3CO₂H + H₂O Typical procedure of this reaction: 37g butanol, 60g glacial acetic acid and 3drops of sulphuric acid (H2SO4) are mixed together. The reaction mixture is then poured into 250cm³ water. The organic layer is separated and washed again with water (100cm³), saturated NaHCO3 (25cm³) and more water (25cm³). The crude ester is then dried over anhydrous Na2SO4 (5g), and then distilled. The yield=40g (69%). MW: C=12 gmot', O=16 gmot¹, H=1 gmot¹ a) Estimate the atom economy of this reaction b) Calculate the amount of waste and E-factor for this reaction c) Compute the effective mass yield for this reaction. d) Estimate the reaction mass efficiency. e) Critically comment why there is discrepancy in the value for yield, E-factor, atom economy, reaction mass efficiency and effective mass yield. Which one do you suggest the best to represent the greenness state of this reaction.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
Question
Transcribed Image Text:The following reaction is showing production of ester using esterification reaction of n-butanol with
acetic acid.
of
+ CH3CO2H
+ H20
Typical procedure of this reaction: 37g butanol, 60g glacial acetic acid and 3drops of sulphuric acid
(H2SO4) are mixed together. The reaction mixture is then poured into 250cm³ water. The organic layer
is separated and washed again with water (100cm³), saturated NaHCO3 (25cm³) and more water
(25cm). The crude ester is then dried over anhydrous Na2SO4 (5g), and then distilled. The yield=40g
(69%). MW: C=12 gmot", O=16 gmot", H=1 gmol"
a) Estimate the atom economy of this reaction
b) Calculate the amount of waste and E-factor for this reaction
c) Compute the effective mass yield for this reaction.
d) Estimate the reaction mass efficiency.
e) Critically comment why there is discrepancy in the value for yield, E-factor, atom economy,
reaction mass efficiency and effective mass yield. Which one do you suggest the best to
represent the greenness state of this reaction.
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