In sugar metabolism, the enzyme phosphoglucose isomerase converts glucose-6-phosphate into fructose-6-phosphate, as shown in the reaction below. The enzyme provides a protonated Glu and a neutral Lys. Propose a three-step acid/base mechanism for this reaction. Hint: the product of the first step is an ene-diol. -203POH₂C но...... HO OH OH OPO3-2 HO OH "OH OH

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In sugar metabolism, the enzyme phosphoglucose isomerase converts glucose-6-phosphate
into fructose-6-phosphate, as shown in the reaction below. The enzyme provides a
protonated Glu and a neutral Lys. Propose a three-step acid/base mechanism for this
reaction. Hint: the product of the first step is an ene-diol.
-203POH₂C
HO....
...OH
HO
OH
OPO3-²
-2
HO
OH
OH
OH
Transcribed Image Text:In sugar metabolism, the enzyme phosphoglucose isomerase converts glucose-6-phosphate into fructose-6-phosphate, as shown in the reaction below. The enzyme provides a protonated Glu and a neutral Lys. Propose a three-step acid/base mechanism for this reaction. Hint: the product of the first step is an ene-diol. -203POH₂C HO.... ...OH HO OH OPO3-² -2 HO OH OH OH
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