The following three derivatives of succinimide are anticonvulsants and have found use in the treatment of epilepsy, particularly petit mal seizures. Ph Ph ČH3 Methsuximide Ethosuximide Phensuximide Following is a synthesis of phensuximide. CN Ph CN Ph CN NaOEt KCN 1. NaOH, H2O Ph-CHO 2. HCI, Н-О 3. Нeat COOEt COOEt NC COOET Ethyl cyanoacetate (A) (B) Benzaldehyde Ph Ph Ph CH;NH2 HOOC COOH EtOOC COOEt (C) (D) CH3 Phensuximide In the conversion of (B) to (C), draw the structure of the product of step 1.
The following three derivatives of succinimide are anticonvulsants and have found use in the treatment of epilepsy, particularly petit mal seizures. Ph Ph ČH3 Methsuximide Ethosuximide Phensuximide Following is a synthesis of phensuximide. CN Ph CN Ph CN NaOEt KCN 1. NaOH, H2O Ph-CHO 2. HCI, Н-О 3. Нeat COOEt COOEt NC COOET Ethyl cyanoacetate (A) (B) Benzaldehyde Ph Ph Ph CH;NH2 HOOC COOH EtOOC COOEt (C) (D) CH3 Phensuximide In the conversion of (B) to (C), draw the structure of the product of step 1.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Transcribed Image Text:The following three derivatives of succinimide are anticonvulsants and have found use in the treatment of epilepsy, particularly petit mal seizures.
Ph.
Ph
`N'
ČH3
ČH3
Methsuximide
Ethosuximide
Phensuximide
Following is a synthesis of phensuximide.
CN
Ph
CN
Ph
CN
NaOEt
KCN
1. NaOH, H2O
Ph-CHO
2. HС, Н20
COOET
H
cOOEt
NC
COOEt
3. Нeat
Ethyl
cyanoacetate
(A)
(B)
Benzaldehyde
Ph.
Ph
Ph
CH3NH2
НООС
СООН
EtOOC
COOET
`N'
(C)
(D)
ČH3
Phensuximide
In the conversion of (B) to (C), draw the structure of the product of step 1.
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