constriction of bronchial tubes. Cromolyn sodium is synthesized in the above series of steps. 1. Treatment of one mole of epichlorohydrin with two moles of 2,6-dihydroxyacetophenone in the presence of base gives I. 2. Treatment of I with two moles of diethyl oxalate in the presence of sodium ethoxide gives a diester II. 3. Saponification of the diester with aqueous NaOH gives cromolyn sodium. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. Arrow-pushing Instructions HO HO :A H-A H3C. :o: :0-H :o: :ö:

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
icon
Related questions
Question
hapter 21
[References)
^ constriction of bronchial tubes.
Cromolyn sodium is synthesized in the above series of steps.
1. Treatment of one mole of epichlorohydrin with two moles of 2,6-dihydroxyacetophenone in the presence of base gives I.
2. Treatment of I with two moles of diethyl oxalate in the presence of sodium ethoxide gives a diester II.
3. Saponification of the diester with aqueous NaOH gives cromolyn sodium.
Draw curved arrows to show the movement of electrons in this step of the reaction mechanism.
Arrow-pushing Instructions
HO
HO
H3C.
:A
H3C.
H-A
:0-H
:0:
:0:
Submit Answer
Try Another Version
1 item attempt remaining
11:25 F
31%
4/20/20
Transcribed Image Text:hapter 21 [References) ^ constriction of bronchial tubes. Cromolyn sodium is synthesized in the above series of steps. 1. Treatment of one mole of epichlorohydrin with two moles of 2,6-dihydroxyacetophenone in the presence of base gives I. 2. Treatment of I with two moles of diethyl oxalate in the presence of sodium ethoxide gives a diester II. 3. Saponification of the diester with aqueous NaOH gives cromolyn sodium. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. Arrow-pushing Instructions HO HO H3C. :A H3C. H-A :0-H :0: :0: Submit Answer Try Another Version 1 item attempt remaining 11:25 F 31% 4/20/20
HO
HO.
OH
base
CI
EIO-
C-OEt
epichlorohydrin
OH
NaOEt
2,6-dihydroxy-
acetophenone
*Na O2C.
.CO2 Na*
NaOH, H2O
II
OH
Cromolyn sodium
Cromolyn sodium, developed during the 1960s, has been used to prevent allergic reactions primarily affecting the lungs, as, for example, exercised-
induced emphysema. It is thought to block the release of histamine, which prevents the sequence of events leading to swelling, itching, and
constriction of bronchial tubes.
v Cromolyn sodium is synthesized in the above series of steps.
rch
31%
11:24 P
4/20/20-
Transcribed Image Text:HO HO. OH base CI EIO- C-OEt epichlorohydrin OH NaOEt 2,6-dihydroxy- acetophenone *Na O2C. .CO2 Na* NaOH, H2O II OH Cromolyn sodium Cromolyn sodium, developed during the 1960s, has been used to prevent allergic reactions primarily affecting the lungs, as, for example, exercised- induced emphysema. It is thought to block the release of histamine, which prevents the sequence of events leading to swelling, itching, and constriction of bronchial tubes. v Cromolyn sodium is synthesized in the above series of steps. rch 31% 11:24 P 4/20/20-
Expert Solution
steps

Step by step

Solved in 2 steps with 1 images

Blurred answer
Knowledge Booster
Ammonium Salts
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Chemistry
Chemistry
Chemistry
ISBN:
9781305957404
Author:
Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:
Cengage Learning
Chemistry
Chemistry
Chemistry
ISBN:
9781259911156
Author:
Raymond Chang Dr., Jason Overby Professor
Publisher:
McGraw-Hill Education
Principles of Instrumental Analysis
Principles of Instrumental Analysis
Chemistry
ISBN:
9781305577213
Author:
Douglas A. Skoog, F. James Holler, Stanley R. Crouch
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9780078021558
Author:
Janice Gorzynski Smith Dr.
Publisher:
McGraw-Hill Education
Chemistry: Principles and Reactions
Chemistry: Principles and Reactions
Chemistry
ISBN:
9781305079373
Author:
William L. Masterton, Cecile N. Hurley
Publisher:
Cengage Learning
Elementary Principles of Chemical Processes, Bind…
Elementary Principles of Chemical Processes, Bind…
Chemistry
ISBN:
9781118431221
Author:
Richard M. Felder, Ronald W. Rousseau, Lisa G. Bullard
Publisher:
WILEY