Homework Help is Here – Start Your Trial Now!
Science
Chemistry
Describe two methods (including important chemical and physical features) you could use to synthesise your n-PrLi

Describe two methods (including important chemical and physical features) you could use to synthesise your n-PrLi

Organic Chemistry
Organic Chemistry
9th Edition
ISBN:9781305080485
Author:John E. McMurry
Publisher:John E. McMurry
Chapter20: Carboxylic Acids And Nitriles
Section20.SE: Something Extra
Problem 25MP: Acid-catalyzed hydrolysis of a nitrile to give a carboxylic acid occurs by initial protonation of...
See similar textbooks
icon
Related questions
icon
Concept explainers
Question

Need help with this question. Thank you :)

(i) Describe two methods (including important chemical and physical features) you could use to synthesise your n-PrLi
Transcribed Image Text:(i) Describe two methods (including important chemical and physical features) you could use to synthesise your n-PrLi
Question 1 Alkylation of valerolactim ethers (1) is an attractive route to a-alkyl-ô-amino acids; important building blocks for medicinally important compounds. After discussion with your supervisor you decide to test two compounds, lithium diisopropylamide (LDA) and n-propyllithium (n-PrLi), as possible metalating reagents. The strategy is To synthesise fresh solutions of LDA and n-PrLi. To test them in reactions with the valerolactim ether (1) To obtain the possible cyclic chiral product on alkylation with benzylbromide LOME valerolactim ether (1)
Transcribed Image Text:Question 1 Alkylation of valerolactim ethers (1) is an attractive route to a-alkyl-ô-amino acids; important building blocks for medicinally important compounds. After discussion with your supervisor you decide to test two compounds, lithium diisopropylamide (LDA) and n-propyllithium (n-PrLi), as possible metalating reagents. The strategy is To synthesise fresh solutions of LDA and n-PrLi. To test them in reactions with the valerolactim ether (1) To obtain the possible cyclic chiral product on alkylation with benzylbromide LOME valerolactim ether (1)
Expert Solution
steps

Step by step

Solved in 2 steps with 1 images

SEE SOLUTIONCheck out a sample Q&A here
Blurred answer
Knowledge Booster
Ionic Equilibrium
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9781305080485
Author:
John E. McMurry
Publisher:
Cengage Learning
SEE MORE TEXTBOOKS