Need help with this question. Thank you :) (i)Describe two methods (including important chemical and physical features) you could use tosynthesise your n-PrLi Question 1Alkylation of valerolactim ethers (1) is an attractive route to a-alkyl-ô-amino acids; importantbuilding blocks for medicinally important compounds. After discussion with your supervisor youdecide to test two compounds, lithium diisopropylamide (LDA) and n-propyllithium (n-PrLi), aspossible metalating reagents. The strategy isTo synthesise fresh solutions of LDA and n-PrLi.To test them in reactions with the valerolactim ether (1)To obtain the possible cyclic chiral product on alkylation with benzylbromideLOMEvalerolactim ether (1)

n-propyllithium (n-PrLi) is an organometallic reagent. It can be synthesized in following ways:

Answered: Describe two methods (including…

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Describe two methods (including important chemical and physical features) you could use to synthesise your n-PrLi

Organic Chemistry

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ISBN:9781305080485

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Publisher:John E. McMurry

Chapter22: Carbonyl Alpha-substitution Reactions

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Need help with this question. Thank you :)

(i)
Describe two methods (including important chemical and physical features) you could use to
synthesise your n-PrLi

Question 1
Alkylation of valerolactim ethers (1) is an attractive route to a-alkyl-ô-amino acids; important
building blocks for medicinally important compounds. After discussion with your supervisor you
decide to test two compounds, lithium diisopropylamide (LDA) and n-propyllithium (n-PrLi), as
possible metalating reagents. The strategy is
To synthesise fresh solutions of LDA and n-PrLi.
To test them in reactions with the valerolactim ether (1)
To obtain the possible cyclic chiral product on alkylation with benzylbromide
LOME
valerolactim ether (1)

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