Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Part 2 out of 2
Devise a synthesis of the biaryl whereby the methyl substituted ring is used to form the organoborane needed for coupling.
![**How many routes are possible for Suzuki coupling of the aromatic rings?**
2
**Part 2 out of 2: Devise a synthesis of the biaryl whereby the methyl substituted ring is used to form the organoborane needed for coupling.**
---
### Synthesis of Methyl Substituted Ring
- **Benzene**
- Step [A,1]
- Options:
- HNO₃, H₂SO₄
- Pd(PPh₃)₄, NaOH
- [1] NaNO₂, HCl; [2] H₂O
- CH₃Cl, AlCl₃
- **Intermediate [A,1]**
- Step [A,2]
- Options:
- Br₂, FeBr₃
- [1] Li; [2] B(OCH₃)₃
- H₂, Pd-C
- [1] NaI; [2] CH₃I
- **Intermediate [A,2]**
- Step [A,3]
- Options:
- Pd(PPh₃)₄, NaOH
- [1] Li; [2] B(OCH₃)₃
- Br₂, FeBr₃
- HNO₃, H₂SO₄
- **Methyl substituted aromatic ring**
---
### Synthesis of Methoxy Substituted Ring
- **Benzene**
- Step [B,1]
- Options:
- Br₂, FeBr₃
- CH₃Cl, AlCl₃
- H₂, Pd-C
- [1] NaNO₂, HCl; [2] H₂O
- **Intermediate [B,1]**
- Step [B,2]
- Options:
- PCC
- [1] NaI; [2] CH₃I
- H₂, Pd-C
- HNO₃, H₂SO₄
- **Intermediate [B,2]**
- Step [B,3]
- Options:
- H₂, Pd-C
- [1] NaNO₂, HCl; [2] H₂O
- Pd(PPh](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fab321fdb-726b-4db7-b7d9-deccfb7940c6%2F1f1a8676-a0c0-4217-8f2e-4faac44152e9%2Fz7cadr_processed.png&w=3840&q=75)
Transcribed Image Text:**How many routes are possible for Suzuki coupling of the aromatic rings?**
2
**Part 2 out of 2: Devise a synthesis of the biaryl whereby the methyl substituted ring is used to form the organoborane needed for coupling.**
---
### Synthesis of Methyl Substituted Ring
- **Benzene**
- Step [A,1]
- Options:
- HNO₃, H₂SO₄
- Pd(PPh₃)₄, NaOH
- [1] NaNO₂, HCl; [2] H₂O
- CH₃Cl, AlCl₃
- **Intermediate [A,1]**
- Step [A,2]
- Options:
- Br₂, FeBr₃
- [1] Li; [2] B(OCH₃)₃
- H₂, Pd-C
- [1] NaI; [2] CH₃I
- **Intermediate [A,2]**
- Step [A,3]
- Options:
- Pd(PPh₃)₄, NaOH
- [1] Li; [2] B(OCH₃)₃
- Br₂, FeBr₃
- HNO₃, H₂SO₄
- **Methyl substituted aromatic ring**
---
### Synthesis of Methoxy Substituted Ring
- **Benzene**
- Step [B,1]
- Options:
- Br₂, FeBr₃
- CH₃Cl, AlCl₃
- H₂, Pd-C
- [1] NaNO₂, HCl; [2] H₂O
- **Intermediate [B,1]**
- Step [B,2]
- Options:
- PCC
- [1] NaI; [2] CH₃I
- H₂, Pd-C
- HNO₃, H₂SO₄
- **Intermediate [B,2]**
- Step [B,3]
- Options:
- H₂, Pd-C
- [1] NaNO₂, HCl; [2] H₂O
- Pd(PPh
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