Protein Denatured a. Show that the fraction of denatured macromolecules, 0, is related to the equilibrium constant, Kd, by 1+ K. b. At pH=2, the standard enthalpy and entropy of formation for the denaturation of the enzyme chymotrypsin are 418 kJ/mol and 1.32 kJ K-l mol', respectively. Use these data to generate a plot that shows the temperature dependence of 0. Assume the enthalpy and entropy change to be independent of temperature. c. The "melting temperature" of a biological molecule is defined as the temperature at which 0=1/2. Determine the "melting temperature" of chymotrypsin at pH=2.

Protein Denatured a. Show that the fraction of denatured macromolecules, 0, is related to the equilibrium constant, Kd, by 1+ K. b. At pH=2, the standard enthalpy and entropy of formation for the denaturation of the enzyme chymotrypsin are 418 kJ/mol and 1.32 kJ K-l mol', respectively. Use these data to generate a plot that shows the temperature dependence of 0. Assume the enthalpy and entropy change to be independent of temperature. c. The "melting temperature" of a biological molecule is defined as the temperature at which 0=1/2. Determine the "melting temperature" of chymotrypsin at pH=2.

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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