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Propose syntheses for each boxed transformation 4A and 4B Use the same starting materials and rules as in #3, above. Diovan - Blood Pressure regulator. Global sales: $60 billion. OH N OPG OPG Br Diovan 1 ON-H SN2 6 5 We will be able to make these before the Final. NaH, THF OPG NH 3 HN-N We will learn how to make NN this compound in Intermediate Organic Chemistry, using two sets of Nobel Prizewinning chemistry. This is an amino acid derivative part of what makes it work as a drug is that it "looks" like a biological product

Propose syntheses for each boxed transformation 4A and 4B Use the same starting materials and rules as in #3, above. Diovan - Blood Pressure regulator. Global sales: $60 billion. OH N OPG OPG Br Diovan 1 ON-H SN2 6 5 We will be able to make these before the Final. NaH, THF OPG NH 3 HN-N We will learn how to make NN this compound in Intermediate Organic Chemistry, using two sets of Nobel Prizewinning chemistry. This is an amino acid derivative part of what makes it work as a drug is that it "looks" like a biological product

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Propose syntheses for each boxed transformation 4A and 4B Use the same starting materials and rules as in #3, above. Diovan - Blood Pressure regulator. Global sales: $60 billion. OH OPG OPG you Br Diovan 1 + N-N 24 These are both renewable products. They can be made without petroleum. H 6 5 We will be able to make these before the Final. methand SN2 OH Your Job OH 4A MeOH H₂SO4 NaH, THF OPG NH + CrO3 H₂SO4 охор 3 OH HN-N NN This is an amino acid derivative - part of what makes it work as a drug is that it "looks" like a biological product We will learn how to make this compound in Intermediate Organic Chemistry, using two sets of Nobel Prizewinning chemistry. These reactions are coming right up in 212. Your Job 4B 1. SOCI₂ 2. XS NH OPG Br NH₂ Think of the OPG group as a methyl group that won't react with anything.
Transcribed Image Text:Propose syntheses for each boxed transformation 4A and 4B Use the same starting materials and rules as in #3, above. Diovan - Blood Pressure regulator. Global sales: $60 billion. OH OPG OPG you Br Diovan 1 + N-N 24 These are both renewable products. They can be made without petroleum. H 6 5 We will be able to make these before the Final. methand SN2 OH Your Job OH 4A MeOH H₂SO4 NaH, THF OPG NH + CrO3 H₂SO4 охор 3 OH HN-N NN This is an amino acid derivative - part of what makes it work as a drug is that it "looks" like a biological product We will learn how to make this compound in Intermediate Organic Chemistry, using two sets of Nobel Prizewinning chemistry. These reactions are coming right up in 212. Your Job 4B 1. SOCI₂ 2. XS NH OPG Br NH₂ Think of the OPG group as a methyl group that won't react with anything.
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Reaction mechanism is to be provided for the conversion 4A and 4B which are required to form the biological product.

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