Complete the multi-step synthesis below by filling in the missing reagents in boxes below. Write neatly, and remember that some steps may require more than one step, or a particular type of solvent, etc. 6. H3C H3C (H2C H. H3C H3C Li H3C CI CuLi OH H3C H3CO H3C Br MgBr H3CO H3CO H3CO
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
In this multistep synthesis, there is one step where , there is inversion in stereochemistry.
This for that step reagent should be chosen in such a way that inversion reaction occurs.
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