Predict the major product of this reaction. Be sure to include the key model tnat predicts the stereochemistry. Will the product be the threo or syn isomer? the 1. CH3Li 2. H₂O
Reactive Intermediates
In chemistry, reactive intermediates are termed as short-lived, highly reactive atoms with high energy. They rapidly transform into stable particles during a chemical reaction. In specific cases, by means of matrix isolation and at low-temperature reactive intermediates can be isolated.
Hydride Shift
A hydride shift is a rearrangement of a hydrogen atom in a carbocation that occurs to make the molecule more stable. In organic chemistry, rearrangement of the carbocation is very easily seen. This rearrangement can be because of the movement of a carbocation to attain stability in the compound. Such structural reorganization movement is called a shift within molecules. After the shifting of carbocation over the different carbon then they form structural isomers of the previous existing molecule.
Vinylic Carbocation
A carbocation where the positive charge is on the alkene carbon is known as the vinyl carbocation or vinyl cation. The empirical formula for vinyl cation is C2H3+. In the vinyl carbocation, the positive charge is on the carbon atom with the double bond therefore it is sp hybridized. It is known to be a part of various reactions, for example, electrophilic addition of alkynes and solvolysis as well. It plays the role of a reactive intermediate in these reactions.
Cycloheptatrienyl Cation
It is an aromatic carbocation having a general formula, [C7 H7]+. It is also known as the aromatic tropylium ion. Its name is derived from the molecule tropine, which is a seven membered carbon atom ring. Cycloheptatriene or tropylidene was first synthesized from tropine.
Stability of Vinyl Carbocation
Carbocations are positively charged carbon atoms. It is also known as a carbonium ion.
Please draw the newman projection of the answer and clearify if it is syn or threo isomer.
![**Predict the Major Product of This Reaction**
In this exercise, you are tasked with predicting the major product of a specific chemical reaction. An important aspect of this prediction involves the use of a key model to forecast the stereochemistry of the resulting compound. The reaction mechanism involves two steps:
1. **Reagent 1:** Methyl lithium (CH₃Li)
2. **Reagent 2:** Water (H₂O)
**Question:** Will the product be the threo or syn isomer?
**Diagram Explanation:**
The starting compound features a ketone group flanked by an aromatic ring on one side and a substituted alkene on the other. The stereochemistry around the alkene shows a hydrogen atom in a wedged orientation, suggesting its 3D spatial configuration.
When methyl lithium (CH₃Li) is added, a nucleophilic attack on the carbonyl carbon of the ketone occurs, resulting in the formation of an alcohol upon subsequent protonation by water.
The stereochemical outcome, whether it forms a threo or syn isomer, depends on the spatial orientation and the approach of the nucleophile relative to the existing groups on the molecule. Analyze possible models to determine this configuration accurately.](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fa6199e40-a650-4a77-ab66-803cd2c39bd7%2F7ab4d3dc-68f6-4535-a0fd-9f89e14f38e5%2Fyvoryu_processed.png&w=3840&q=75)
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