Piperazinone derivatives, such as compound 4, are being investigated for their potential use in the treatment of migraines as well as a variety of other diseases, including hypertension and sepsis. The following two-step synthetic procedure was developed as a general method for producing a variety of piperazinone derivatives (Tetrahedron Lett. 2009, 50, 3817-3819). Compound 1 is a readily available starting material that can be converted to compound 2 via an SN2 process. Reductive amination of compound 2 affords compound 3 which is short-lived and rapidly undergoes acid-catalyzed amide formation to the cyclic product 4a, piperazinone derivative. 1 H₂N. Br OMe NaHCO3 DMF Challenge Problem 22.100a Incorrect. OMe 2 PhCH,NH NaBH3CN 3 AcOH, heat Draw the structure of compound 3. If it is a pair of diastereomers, draw both diastereomers. Do NOT use abbreviations such as Ph or OMe when drawing the structure(s). Draw Your Solution
Analyzing Infrared Spectra
The electromagnetic radiation or frequency is classified into radio-waves, micro-waves, infrared, visible, ultraviolet, X-rays and gamma rays. The infrared spectra emission refers to the portion between the visible and the microwave areas of electromagnetic spectrum. This spectral area is usually divided into three parts, near infrared (14,290 – 4000 cm-1), mid infrared (4000 – 400 cm-1), and far infrared (700 – 200 cm-1), respectively. The number set is the number of the wave (cm-1).
IR Spectrum Of Cyclohexanone
It is the analysis of the structure of cyclohexaone using IR data interpretation.
IR Spectrum Of Anisole
Interpretation of anisole using IR spectrum obtained from IR analysis.
IR Spectroscopy
Infrared (IR) or vibrational spectroscopy is a method used for analyzing the particle's vibratory transformations. This is one of the very popular spectroscopic approaches employed by inorganic as well as organic laboratories because it is helpful in evaluating and distinguishing the frameworks of the molecules. The infra-red spectroscopy process or procedure is carried out using a tool called an infrared spectrometer to obtain an infrared spectral (or spectrophotometer).
![Piperazinone derivatives, such as compound 4, are being investigated for their potential use in the treatment of migraines as well as a
variety of other diseases, including hypertension and sepsis. The following two-step synthetic procedure was developed as a general
method for producing a variety of piperazinone derivatives (Tetrahedron Lett. 2009, 50, 3817-3819). Compound 1 is a readily available
starting material that can be converted to compound 2 via an SN2 process. Reductive amination of compound 2 affords compound 3
which is short-lived and rapidly undergoes acid-catalyzed amide formation to the cyclic product 4a, piperazinone derivative.
1
H₂N.
OMe
Br
NaHCO3
DMF
2
PhCH, NH
NaBH3CN
AcOH, heat
4
[3]
Challenge Problem 22.100a
Incorrect.
OMe
Draw the structure of compound 3. If it is a pair of diastereomers, draw both diastereomers. Do NOT use abbreviations such as Ph
or OMe when drawing the structure(s).
Draw Your Solution](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F179fe2c7-ddab-4b96-93c1-14d1f4d2aae9%2Fa7e3d8e8-72f1-4796-bbe2-fc598f204664%2Fn5rwx1g_processed.jpeg&w=3840&q=75)
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