A retrosynthetic analysis of 1 was undertaken suggesting a forward synthesis starting from compounds 2, 5 and 6. OH OH H2N. Br (b) NH2 но 5

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Describe a synthetic plan with suitable justification of the sequence of reactions you would understate to complete synthesis of compound 1 from compounds 2,3,4. Suggest suitable reagents 

A retrosynthetic analysis of 1 was undertaken suggesting a forward synthesis starting from
compounds 2, 5 and 6.
F3C
OH
F3C.
H2N.
Br
A (a)
(b)
NH2
4,
но
3.
2.
Transcribed Image Text:A retrosynthetic analysis of 1 was undertaken suggesting a forward synthesis starting from compounds 2, 5 and 6. F3C OH F3C. H2N. Br A (a) (b) NH2 4, но 3. 2.
In order to complete the synthesis of 1 from compounds 2, 3, and 4, describe a
synthetic plan with suitable justification of the sequence of reactions you would
undertake. Suggest suitable reagents for all your proposed reactions.
(d)
CF3
CF3
HO
OH
H2N.
Br
NH2
(2)
(3)
(4)
(1)
Transcribed Image Text:In order to complete the synthesis of 1 from compounds 2, 3, and 4, describe a synthetic plan with suitable justification of the sequence of reactions you would undertake. Suggest suitable reagents for all your proposed reactions. (d) CF3 CF3 HO OH H2N. Br NH2 (2) (3) (4) (1)
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