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PhMgBr H30+ HO. Ph

PhMgBr H30+ HO. Ph

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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### Grignard Reaction with Cyclohexanone **Chemical Equation:** Starting Material: Cyclohexanone Reagent: Phenylmagnesium bromide (PhMgBr) Product: Cyclohexanol with a phenyl group **Reaction Overview:** Cyclohexanone, drawn as a six-membered ring with a ketone functional group (C=O), is reacted with phenylmagnesium bromide (PhMgBr), a Grignard reagent. The reaction is followed by an acid workup with H3O⁺ to produce the final alcohol product. **Product Structure:** The final product is cyclohexanol containing a hydroxyl group (OH) and a phenyl group (Ph) attached to the same carbon. The structure maintains the ring configuration, showing the addition of these groups. **Summary:** The diagram shows the Grignard reaction process where a ketone is converted into an alcohol through nucleophilic addition. The Grignard reagent adds a phenyl group to the carbonyl carbon, and subsequent hydrolysis yields the alcohol, showcasing a fundamental synthetic transformation in organic chemistry.
Transcribed Image Text:### Grignard Reaction with Cyclohexanone **Chemical Equation:** Starting Material: Cyclohexanone Reagent: Phenylmagnesium bromide (PhMgBr) Product: Cyclohexanol with a phenyl group **Reaction Overview:** Cyclohexanone, drawn as a six-membered ring with a ketone functional group (C=O), is reacted with phenylmagnesium bromide (PhMgBr), a Grignard reagent. The reaction is followed by an acid workup with H3O⁺ to produce the final alcohol product. **Product Structure:** The final product is cyclohexanol containing a hydroxyl group (OH) and a phenyl group (Ph) attached to the same carbon. The structure maintains the ring configuration, showing the addition of these groups. **Summary:** The diagram shows the Grignard reaction process where a ketone is converted into an alcohol through nucleophilic addition. The Grignard reagent adds a phenyl group to the carbonyl carbon, and subsequent hydrolysis yields the alcohol, showcasing a fundamental synthetic transformation in organic chemistry.
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