Pharmacogenetics is the study of the effects of genetic factors on drug responses in patients. Interindividual differences in the sequences of genes that encode the drug’s molecular target or transporters, or the enzymes responsible for drug metabolism, can profoundly affect the success or failure of a drug or therapeutic. Which of the following genetic variations would NOT lead to pharmacodynamic variation?
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Pharmacogenetics is the study of the effects of genetic factors on drug responses in patients. Interindividual differences in the sequences of genes that encode the drug’s molecular target or transporters, or the enzymes responsible for drug
Genetic variation leading to altered activity of enzymes involved in drug metabolism.
Genetic variation leading to altered expression of the drug’s molecular target.
Genetic variation leading to decreased affinity of a drug for a receptor.
Genetic variation leading to altered downstream signaling.
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