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Part III – The Second Hit Questions A second hit might occur through epigenetic alterations. In the promoter of RBI, there is a CpG island. Knowing this, how might you predict that a cell could epigenetically inactivate RBItranscription? I. 2. A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in Figure | (next page). Discuss and interpret this model with your group. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene. 3. . One of the ways that we know what the RB protein does in cells is that its inactivation is a common priority of tumor-initiating viruses. a. What advantage would a virus gain by inactivating RB function in its host cell? b. One example of a DNA virus (a virus that uses DNA, not RNA, as its genetic material) that causes tumors is human papillomavirus (HP V). Do some research and explain how HPV inactivates the RB protein and indicate with which type(s) of cancer it is associated. Don't forget to cite your sources!

Part III – The Second Hit Questions A second hit might occur through epigenetic alterations. In the promoter of RBI, there is a CpG island. Knowing this, how might you predict that a cell could epigenetically inactivate RBItranscription? I. 2. A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in Figure | (next page). Discuss and interpret this model with your group. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene. 3. . One of the ways that we know what the RB protein does in cells is that its inactivation is a common priority of tumor-initiating viruses. a. What advantage would a virus gain by inactivating RB function in its host cell? b. One example of a DNA virus (a virus that uses DNA, not RNA, as its genetic material) that causes tumors is human papillomavirus (HP V). Do some research and explain how HPV inactivates the RB protein and indicate with which type(s) of cancer it is associated. Don't forget to cite your sources!

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Part III – The Second Hit Questions A second hit might occur through epigenetic alterations. In the promoter of RBI, there is a CpG island. Knowing this, how might you predict that a cell could epigenetically inactivate RBItranscription? I. 2. A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in Figure I (next page). Discuss and interpret this model with your group. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene. One of the ways that we know what the RB protein does in cells is that its inactivation is a common priority of tumor-initiating viruses. a. What advantage would a virus gain by inactivating RB function in its host cell? b. One example of a DNA virus (a virus that uses DNA, not RNA, as its genetic material) that causes tumors is human papillomavirus (HPV). Do some research and explain how HPV inactivates the RB protein and indicate with which type(s) of cancer it is associated. Don't forget to cite your sources! 3.
Transcribed Image Text:Part III – The Second Hit Questions A second hit might occur through epigenetic alterations. In the promoter of RBI, there is a CpG island. Knowing this, how might you predict that a cell could epigenetically inactivate RBItranscription? I. 2. A second hit might also occur through loss of heterozygosity (LOH). An example of how LOH may occur by reciprocal crossing over during mitosis is diagrammed in Figure I (next page). Discuss and interpret this model with your group. Write a brief explanation of (a) what LOH means and (b) how LOH by mitotic reciprocal crossing over can give rise to a cell lineage with functional loss of the wild-type copy of a tumor suppressor gene. One of the ways that we know what the RB protein does in cells is that its inactivation is a common priority of tumor-initiating viruses. a. What advantage would a virus gain by inactivating RB function in its host cell? b. One example of a DNA virus (a virus that uses DNA, not RNA, as its genetic material) that causes tumors is human papillomavirus (HPV). Do some research and explain how HPV inactivates the RB protein and indicate with which type(s) of cancer it is associated. Don't forget to cite your sources! 3.
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