*In the presence of saturating amounts of oxaloacetate, the activityof citrate synthase from pig heart tissue shows a sigmoidal dependenceon the concentration of acetyl-SCOA as shown below.SCOA is added, the curve shifts to the right and becomes even moresigmoidal. On the basis of these observations, explain how succinyl-SCOA regulates the activity of citrate synthase. Why is succinyl-SCOAan appropriate signal for regulation of the citric acid cycle?does the regulation of citrate synthase control the rate of cellularrespiration in pig heart tissue?100 -80 succinyl-CoAActivity (% of V,6040-NoSuccinyl-CoAadded20 40 60 80 100 120[Acetyl-CoAl(pM)-How-

In presence of succinyl Coenzyme A, the sigmoidal curve shifted to the right and becomes even more…

of citrate synthase from pig heart tissue shows a sigmoidal dependenc *In the presence of saturating amounts of oxaloacetate, the act on the concentration of acetyl-SCOA as shown below. sigmoidal. When succinyl- SCOA is added, the curve shifts to the right and becomes even more SCOA regulates the activity of citrate synthase. On the basis of these observations, explain how succinyl- an appropriate signal for regulation of the citric acid cycle? does the regulation of citrate synthase control the rate of cellular Why is succinyl-SCOA How respiration in pig heart tissue? Activity (% of Vmax) 100- No succinyl-CoA J 40 - added 40 60 (Acetyl-CoA) (µM) 80 60 20 20 Succinyl-CoA 100 120 80

of citrate synthase from pig heart tissue shows a sigmoidal dependenc *In the presence of saturating amounts of oxaloacetate, the act on the concentration of acetyl-SCOA as shown below. sigmoidal. When succinyl- SCOA is added, the curve shifts to the right and becomes even more SCOA regulates the activity of citrate synthase. On the basis of these observations, explain how succinyl- an appropriate signal for regulation of the citric acid cycle? does the regulation of citrate synthase control the rate of cellular Why is succinyl-SCOA How respiration in pig heart tissue? Activity (% of Vmax) 100- No succinyl-CoA J 40 - added 40 60 (Acetyl-CoA) (µM) 80 60 20 20 Succinyl-CoA 100 120 80

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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Concept explainers

Polymerization Kinetics

Polymerization is a chemical process in which one or more monomers combine to produce a very large chain-like molecule called a polymer. The functional groups present on the monomers and their steric effects are responsible for polymerization through a sequence of reactions that diverge in complexity. There exists a stable covalent chemical bond between monomers that sets apart polymerization from other processes. Polymerization is generally classified into step-growth and chain polymerization. Polymers are categorized into linear polymer and cross-linked polymers that are produced either by condensation or additional polymerization.

Question

*In the presence of saturating amounts of oxaloacetate, the activity
of citrate synthase from pig heart tissue shows a sigmoidal dependence
on the concentration of acetyl-SCOA as shown below.
SCOA is added, the curve shifts to the right and becomes even more
sigmoidal. On the basis of these observations, explain how succinyl-
SCOA regulates the activity of citrate synthase. Why is succinyl-SCOA
an appropriate signal for regulation of the citric acid cycle?
does the regulation of citrate synthase control the rate of cellular
respiration in pig heart tissue?
100 -
80 succinyl-CoA
Activity (% of V,
60
40-
No
Succinyl-CoA
added
20 40 60 80 100 120
[Acetyl-CoAl(pM)
-
How
-

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