Phosphoglycerate mutase mechanism is shown below: Phosphoglycerate mutase His His 2-0,pN+ "ooc H-C-0-PO N: H+ H,c-0-PO 3-Phosphoglycerate 2,3-Bisphosphoglycerate (2,3-BPG) HN HN His His His His 2-0,P-N* H-C-0-PO; -ooc H-C-0-PO H,C-0-Po 2,3-Bisphosphoglycerate N+ H,C-0-H (2,3-BPG) HN 2-Phosphoglycerate HN -His -His A) What is the role of P on His in step 1? [Select] B) What is the role of the ring nitrogen (with the lone pair shown) of the nonphosphorylated His residue in step 1? [ Select ] C) What is the electrophile in step 2. [ Select] D) What is the role of NH* of the lower His residue in step 2? general base

Phosphoglycerate mutase mechanism is shown below: Phosphoglycerate mutase His His 2-0,pN+ "ooc H-C-0-PO N: H+ H,c-0-PO 3-Phosphoglycerate 2,3-Bisphosphoglycerate (2,3-BPG) HN HN His His His His 2-0,P-N* H-C-0-PO; -ooc H-C-0-PO H,C-0-Po 2,3-Bisphosphoglycerate N+ H,C-0-H (2,3-BPG) HN 2-Phosphoglycerate HN -His -His A) What is the role of P on His in step 1? [Select] B) What is the role of the ring nitrogen (with the lone pair shown) of the nonphosphorylated His residue in step 1? [ Select ] C) What is the electrophile in step 2. [ Select] D) What is the role of NH* of the lower His residue in step 2? general base

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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