Phosphoglycerate mutase mechanism is shown below: Phosphoglycerate mutase His His 2-0,pN+ "ooc H-C-0-PO N: H+ H,c-0-PO 3-Phosphoglycerate 2,3-Bisphosphoglycerate (2,3-BPG) HN HN His His His His 2-0,P-N* H-C-0-PO; -ooc H-C-0-PO H,C-0-Po 2,3-Bisphosphoglycerate N+ H,C-0-H (2,3-BPG) HN 2-Phosphoglycerate HN -His -His A) What is the role of P on His in step 1? [Select] B) What is the role of the ring nitrogen (with the lone pair shown) of the nonphosphorylated His residue in step 1? [ Select ] C) What is the electrophile in step 2. [ Select] D) What is the role of NH* of the lower His residue in step 2? general base
Phosphoglycerate mutase mechanism is shown below: Phosphoglycerate mutase His His 2-0,pN+ "ooc H-C-0-PO N: H+ H,c-0-PO 3-Phosphoglycerate 2,3-Bisphosphoglycerate (2,3-BPG) HN HN His His His His 2-0,P-N* H-C-0-PO; -ooc H-C-0-PO H,C-0-Po 2,3-Bisphosphoglycerate N+ H,C-0-H (2,3-BPG) HN 2-Phosphoglycerate HN -His -His A) What is the role of P on His in step 1? [Select] B) What is the role of the ring nitrogen (with the lone pair shown) of the nonphosphorylated His residue in step 1? [ Select ] C) What is the electrophile in step 2. [ Select] D) What is the role of NH* of the lower His residue in step 2? general base
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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![Phosphoglycerate mutase mechanism is shown below:
Phosphoglycerate mutase
His
His
2-0,pN+
"ooc
H-C-0-PO
N:
H+
H,c-0-PO
3-Phosphoglycerate
2,3-Bisphosphoglycerate
(2,3-BPG)
HN
HN
His
His
His
His
2-0,P-N*
H-C-0-PO;
-ooc
H-C-0-PO
H,C-0-Po
2,3-Bisphosphoglycerate
N+
H,C-0-H
(2,3-BPG)
HN
2-Phosphoglycerate HN
-His
-His
A) What is the role of P on His in step 1? [Select]
B) What is the role of the ring nitrogen (with the lone pair shown) of the
nonphosphorylated His residue in step 1? [ Select ]
C) What is the electrophile in step 2. [ Select]
D) What is the role of NH* of the lower His residue in step 2? general base](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F7270fe1e-0111-45ae-aa47-a2733f262922%2Fa02dc016-6361-453a-9ead-9797ee7fbfe9%2Fvjnjv6n_processed.png&w=3840&q=75)
Transcribed Image Text:Phosphoglycerate mutase mechanism is shown below:
Phosphoglycerate mutase
His
His
2-0,pN+
"ooc
H-C-0-PO
N:
H+
H,c-0-PO
3-Phosphoglycerate
2,3-Bisphosphoglycerate
(2,3-BPG)
HN
HN
His
His
His
His
2-0,P-N*
H-C-0-PO;
-ooc
H-C-0-PO
H,C-0-Po
2,3-Bisphosphoglycerate
N+
H,C-0-H
(2,3-BPG)
HN
2-Phosphoglycerate HN
-His
-His
A) What is the role of P on His in step 1? [Select]
B) What is the role of the ring nitrogen (with the lone pair shown) of the
nonphosphorylated His residue in step 1? [ Select ]
C) What is the electrophile in step 2. [ Select]
D) What is the role of NH* of the lower His residue in step 2? general base
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