Nevirapine is a reversible non-competitive inhibitor of the AIDS virus reversed transcriptase. It is in the NNRTI (non-nucleoside reversed transcriptase inhibitors) class of medications. a.) What advantage over nucleoside based reversed transcriptase inhibitors like 3'-azidothymidine was anticipated for the non-nucleoside reversed transcriptase inhibitors? CH3 4 HINS 5 Nevirapine b.) What method was used to discover the initial lead compound possessing low potency reversed transcriptase inhibition activity? c.) Does nevirapine compete with the 2'-deoxynucleoside 5'-triphosphates for occupancy of the enzyme catalytic site?

Nevirapine is a reversible non-competitive inhibitor of the AIDS virus reversed transcriptase. It is in the NNRTI (non-nucleoside reversed transcriptase inhibitors) class of medications. a.) What advantage over nucleoside based reversed transcriptase inhibitors like 3'-azidothymidine was anticipated for the non-nucleoside reversed transcriptase inhibitors? CH3 4 HINS 5 Nevirapine b.) What method was used to discover the initial lead compound possessing low potency reversed transcriptase inhibition activity? c.) Does nevirapine compete with the 2'-deoxynucleoside 5'-triphosphates for occupancy of the enzyme catalytic site?

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

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