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HIV reverse transcriptase is highly error-prone, because there is no proofreading mechanism associated with this enzyme. In fact, a typical error rate is 10 errors per genome replication. For the purposes of a straightforward calculation, let's consider a simplified scenario: early in infection, HIV is thought to have a virus doubling time of 0.65 days. If reverse transcriptase errors were the only source of mutations/errors in HIV, then how many total mutations would all HIV virions have developed 2.6 days after initial infection assuming an individual was initially infected with only one HIV virion?

HIV reverse transcriptase is highly error-prone, because there is no proofreading mechanism associated with this enzyme. In fact, a typical error rate is 10 errors per genome replication. For the purposes of a straightforward calculation, let's consider a simplified scenario: early in infection, HIV is thought to have a virus doubling time of 0.65 days. If reverse transcriptase errors were the only source of mutations/errors in HIV, then how many total mutations would all HIV virions have developed 2.6 days after initial infection assuming an individual was initially infected with only one HIV virion?

Chemistry
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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HIV reverse transcriptase is highly error-prone, because there is no proofreading mechanism associated with this enzyme. In fact, a typical error rate is 10 errors per genome replication. For the purposes of a straightforward calculation, let's consider a simplified scenario: early in infection, HIV is thought to have a virus doubling time of 0.65 days. If reverse transcriptase errors were the only source of mutations/errors in HIV, then how many total mutations would all HIV virions have developed 2.6 days after initial infection assuming an individual was initially infected with only one HIV virion?
Transcribed Image Text:HIV reverse transcriptase is highly error-prone, because there is no proofreading mechanism associated with this enzyme. In fact, a typical error rate is 10 errors per genome replication. For the purposes of a straightforward calculation, let's consider a simplified scenario: early in infection, HIV is thought to have a virus doubling time of 0.65 days. If reverse transcriptase errors were the only source of mutations/errors in HIV, then how many total mutations would all HIV virions have developed 2.6 days after initial infection assuming an individual was initially infected with only one HIV virion?
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