N H N-H ZI H Saquinavir N H H 1. Identify any single bonds in saquinavir that have restricted rotation and are thus not counted towards the number of rotatable bonds identified for Veber's parameters
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- 6. The [a] of cheatalotic acid is + 10°. The structure shown below was thought to be correct. Answer for Part b HO, COOH H, HO OH Cheatalotic Acid Incorrect Structure a) Why is the structure shown incorrect? b) Propose a cture of cheatalotic acid that can possibly be correct, assuming atom connectivity is correc2) Consider the following disaccharide which was formed from the breakdown of a polysaccharide found in plant material. ОН Glycosidic linkage: H H OH H H НО H H. OH H. ОН OH H НО H ОН a. Label the glycosidic linkage above in the following format: a/B(# → #) b. Would you expect this disaccharide to have been formed from amylose or amylopectin? c. Describe at least two chemical tests that would give insight into the structure of this disaccharide, assuming you've isolated it and wanted to elucidate the structure from scratch. Include detail on not only the tests you would use but what results you would expect to get given the structure above. Assume you can analyze the structure of any monosaccharide you get from your chemical tests.NH3* *H3N Give the abbreviation for the above tripeptide using the three-letter codes for each amino acid. Z-エ の エ-Z
- 1. (a) The diagram below shows a structure of monosaccharide. CH,OH C=0 H-C-OH НО—С—Н ČH,OH i. Draw the figure above on your answer sheet and indicate ALL chiral carbon(s) in your figure with *. ii. With reference to the number of carbon, the type of carbonyl group and D/L configuration, suggest a name consisting these three properties to describe the monosaccharide shown above. Explain why this monosaccharide is in D- or L- configuration as you suggested in (ii). 111. (b) The diagram below shows different configurations of glucose. CH,OH CHO ÇH,OH H H-C-OH O. OH H. H. OH H. H OH HO-C-H но H-C-OH но H. H-C-OH OH OH ČH,OH A В C i. Which glucose molecule, A or C, is in a configuration? Explain. ii. What is the name of the conversion among different configurations? iii. Glycosaminoglycans (GAG) consist of modified sugars. Give a name of the typical modification to the sugar. What makes GAG ideal for the fluid in the joints? to23In the following questions, consider the carbanion formed by the arrow pushing below: он | HC-C-R H ཋཙམཏིཏཡརིཡཐཱ པཱལཾ ཏིཡཏིཡ, B: H C-C-R Н Question 7 2 pts Below are a proposed resonance structure of the carbanion and rules of resonance. Which rules, if any, does the resonance structure break? (Select all that apply.) Ο Η | │ C-C-R H The formal charge of the molecule cannot change. ☐ Single (sigma) bonds cannot be broken. With the exception of carbocations, octet rules must be satisfied. ☐ All of the above rules are satisfied.
- I. Write a balanced chemical reaction, complete with chemical structures, to show the hydrolysis of iso-C to U. II. Draw the mechanism by which iso-G converts to its "minor tautomeric form complementary to U." You may propose either an acid or base catalyst. III. Draw chemical structures of the minor tautomeric form of iso-guanine (iso-G) and uracil (U), showing the non-covalent bonding (H-bonding) interactions between them.Hhhh