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Which analogue involves a retroinverso peptide isostere? CH₂ A с CH3 Ö G O NH FX NH S OH OH S B D S OH 0-2 oxacillin antibiotic CH₂ CH₂ IZ FO I I OH -OH

Which analogue involves a retroinverso peptide isostere? CH₂ A с CH3 Ö G O NH FX NH S OH OH S B D S OH 0-2 oxacillin antibiotic CH₂ CH₂ IZ FO I I OH -OH

Biochemistry
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
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Identifying isosteres; selecting isosteres. The structure of oxacillin, an antibiotic, is shown below with six different analogues involving an isosteric substitution. Which analogue involves a retroinverso peptide isostere? A C CH3 CI NH IZ I о CH₂ NH Bix X о -S -OH OH B D S OH 0-2 oxacillin antibiotic CH3 CH3 O IZ I Is огон OH OH I
Transcribed Image Text:Identifying isosteres; selecting isosteres. The structure of oxacillin, an antibiotic, is shown below with six different analogues involving an isosteric substitution. Which analogue involves a retroinverso peptide isostere? A C CH3 CI NH IZ I о CH₂ NH Bix X о -S -OH OH B D S OH 0-2 oxacillin antibiotic CH3 CH3 O IZ I Is огон OH OH I
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