My follow up question is Are the genes mention previously important to adencarcinoma tumours in colorectal cancer in humans which is MSH1 MSH2.
As with inflammatory bowel disease (IBD) or chronic gastritis brought on by Helicobacter pylori infection, persistent inflammation is frequently present in gastrointestinal mucosal areas that are more likely to develop cancer. Unsolved issues include why some patients experience more mucosal inflammation than others and why some people with chronic inflammation go on to acquire cancer. IBD and other types of chronic inflammation have not been associated with highly penetrant single gene mutations, in contrast to the syndromic forms of familial colorectal cancer (CRC).
In genome-wide association studies, single nucleotide polymorphisms (SNPs) are differences in the DNA sequence that can be connected to any condition (cancer, chronic inflammation, etc). (GWAS). Several highly penetrant single gene loci and numerous SNP have both been connected to CRC. In the majority of cases, the propensity to develop IBD has not been associated with a single gene mutation, but rather with SNPs at the NOD2 locus (which appear to produce hypomorphic alleles for this bacterial response gene), the IL23R locus, the autophagy gene ATG16L1, and a variety of other loci, including the Toll-like receptors, JAK2 and STAT3, and possibly 70 more.
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